{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T13:56:17Z","timestamp":1792331777111,"version":"4.4.0"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T00:00:00Z","timestamp":1394409600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p><jats:italic>Toxoplasma gondii<\/jats:italic>is a major cause of congenital brain disease; however, the underlying mechanism of neuropathogenesis in brain toxoplasmosis remains elusive. To explore the role of<jats:italic>T. gondii<\/jats:italic>in the development of neural stem cells (NSCs), NSCs were isolated from GD14 embryos of ICR mice and were co-cultured with tachyzoites of<jats:italic>T. gondii<\/jats:italic>RH strain. We found that apoptosis levels of the NSCs co-cultured with 1\u00d710<jats:sup>6<\/jats:sup>RH tachyzoites for 24 and 48\u00a0h significantly increased in a dose-dependent manner, as compared with the control. Western blotting analysis displayed that the protein level of C\/EBP homologous protein (CHOP) was up-regulated, and caspase-12 and c-Jun N-terminal kinase (JNK) were activated in the NSCs co-cultured with the parasites. Pretreatment with endoplasmic reticulum stress (ERS) inhibitor (TUDCA) and caspase-12 inhibitor (Z-ATAD-FMK) inhibited the expression or activation of the key molecules involved in the ERS-mediated apoptotic pathway, and subsequently decreased the apoptosis levels of the NSCs induced by the<jats:italic>T. gondii.<\/jats:italic>The findings here highlight that<jats:italic>T. gondii<\/jats:italic>induced apoptosis of the NSCs through the ERS signal pathway via activation of CHOP, caspase-12 and JNK, which may constitute a potential molecular mechanism responsible for the cognitive disturbance in neurological disorders of<jats:italic>T. gondii<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0031182014000183","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T13:02:35Z","timestamp":1394456555000},"page":"988-995","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":46,"title":["<i>Toxoplasma gondii<\/i>induce 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