{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:18:00Z","timestamp":1781720280073,"version":"3.54.5"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T00:00:00Z","timestamp":1404777600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>As the currently only available molluscicide, niclosamide has been widely used for snail control for over 2 decades in China. There is therefore a concern about the emergence of niclosamide-resistant snail populations following repeated, extensive use of the chemical. The purpose of this study was to investigate the likelihood of niclosamide resistance in <jats:italic>Oncomelania hupensis<\/jats:italic> in China. Active adult <jats:italic>O. hupensis<\/jats:italic> snails derived from 20 counties of 10 schistosomiasis-endemic provinces of China, of 10 snails in each drug concentration, were immersed in solutions of 1, 0\u00b75, 0\u00b725, 0\u00b7125, 0\u00b7063, 0\u00b7032, 0\u00b7016 and 0\u00b7008\u00a0mg\u00a0L<jats:sup>\u22121<\/jats:sup> of a 50% wettable powder of niclosamide ethanolamine salt (WPN) for 24 and 48\u00a0h at 25\u00a0\u00b0C, and the median lethal concentration (LC<jats:sub>50<\/jats:sub>) was estimated. Then, the 24- and 48-h WPN LC<jats:sub>50<\/jats:sub> values were compared with those determined in the same sampling sites in 2002. The results indicated that the 24- and 48-h WPN LC<jats:sub>50<\/jats:sub> values for <jats:italic>O. hupensis<\/jats:italic> were not significantly different from those determined in 2002 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7202 and 0\u00b7796, respectively). It is concluded that the current sensitivity of <jats:italic>O. hupensis<\/jats:italic> to niclosamide has not changed after more than 2 decades of repeated, extensive application in the main endemic foci of China, and there is no evidence of resistance to niclosamide detected in <jats:italic>O. hupensis<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0031182014000870","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T13:14:58Z","timestamp":1404825298000},"page":"332-340","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":25,"title":["Resistance to niclosamide in <i>Oncomelania hupensis<\/i>, the intermediate host of <i>Schistosoma japonicum<\/i>: should we be worried?"],"prefix":"10.1017","volume":"142","author":[{"given":"JIAN-RONG","family":"DAI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOU-ZI","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WEI","family":"WANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YUN-TIAN","family":"XING","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GUO-LI","family":"QU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOU-SHENG","family":"LIANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,7,8]]},"reference":[{"key":"S0031182014000870_ref25","volume-title":"The Role of Mollusciciding in Schistosomiasis Control","year":"1992"},{"key":"S0031182014000870_ref19","first-page":"975","article-title":"Bilharziasis control by application of molluscicides; a review of its present status","volume":"18","author":"Paulini","year":"1958","journal-title":"Bulletin of the World Health Organization"},{"key":"S0031182014000870_ref2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1383-5769(99)00004-5","article-title":"Schistosomiasis control in China","volume":"48","author":"Chen","year":"1999","journal-title":"Parasitology International"},{"key":"S0031182014000870_ref13","doi-asserted-by":"publisher","DOI":"10.4081\/gh.2009.222"},{"key":"S0031182014000870_ref27","first-page":"474","article-title":"Progress of research on molluscicides","volume":"18","author":"Wu","year":"2006","journal-title":"Chinese Journal of Schistosomiasis Control"},{"key":"S0031182014000870_ref8","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph110303086"},{"key":"S0031182014000870_ref37","doi-asserted-by":"publisher","DOI":"10.3201\/eid1310.061423"},{"key":"S0031182014000870_ref15","volume-title":"Biology of Schistosome and Control of Schistosomiasis","author":"Mao","year":"1990"},{"key":"S0031182014000870_ref5","first-page":"122","article-title":"Studies on standardization of methods for screening molluscicides in laboratory. 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