{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:31:03Z","timestamp":1773387063321,"version":"3.50.1"},"reference-count":47,"publisher":"Cambridge University Press (CUP)","issue":"13","license":[{"start":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:00:00Z","timestamp":1407196800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Antibodies (Ab) recognizing G-protein coupled receptors, such as<jats:italic>\u03b2<\/jats:italic><jats:sub>1<\/jats:sub>and<jats:italic>\u03b2<\/jats:italic><jats:sub>2<\/jats:sub>adrenergic (anti-<jats:italic>\u03b2<\/jats:italic><jats:sub>1<\/jats:sub>-AR and anti-<jats:italic>\u03b2<\/jats:italic><jats:sub>2<\/jats:sub>-AR, respectively) and muscarinic cholinergic receptors (anti-M<jats:sub>2<\/jats:sub>-CR) may contribute to cardiac damage, however their role in chronic chagasic cardiomyopathy is still controversial. We describe that<jats:italic>Trypanosoma cruzi<\/jats:italic>-infected C3H\/He mice show increased P and QRS wave duration, and PR and QTc intervals, while the most significant ECG alterations in C57BL\/6 are prolonged P wave and PR interval. Echocardiogram analyses show right ventricle dilation in infected animals of both mouse lineages. Analyses of heart rate variability (HRV) in chronically infected C3H\/He mice show no alteration of the evaluated parameters, while C57BL\/6 infected mice display significantly lower values of HRV components, suggesting autonomic dysfunction. The time-course analysis of anti-<jats:italic>\u03b2<\/jats:italic><jats:sub>1<\/jats:sub>-AR, anti-<jats:italic>\u03b2<\/jats:italic><jats:sub>2<\/jats:sub>-AR and anti-M<jats:sub>2<\/jats:sub>-CR Ab titres in C3H\/He infected mice indicate that anti-<jats:italic>\u03b2<\/jats:italic><jats:sub>1<\/jats:sub>-AR Ab are detected only in the chronic phase, while anti-<jats:italic>\u03b2<\/jats:italic><jats:sub>2<\/jats:sub>-AR and anti-M<jats:sub>2<\/jats:sub>-CR are observed in the acute phase, diminish at 60\u00a0dpi and increase again in the chronic phase. Chronically infected C57BL\/6 mice presented a significant increase in only anti-M<jats:sub>2<\/jats:sub>-CR Ab titres. Furthermore, anti-<jats:italic>\u03b2<\/jats:italic><jats:sub>1<\/jats:sub>-AR, anti-<jats:italic>\u03b2<\/jats:italic><jats:sub>2<\/jats:sub>-AR and anti-M<jats:sub>2<\/jats:sub>-CR, exhibit significantly higher prevalence in chronically<jats:italic>T. cruzi<\/jats:italic>-infected C3H\/He mice when compared with C57BL\/6. These observations suggest that<jats:italic>T. cruzi<\/jats:italic>infection leads to host-specific cardiac electric alterations.<\/jats:p>","DOI":"10.1017\/s0031182014001097","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T12:55:45Z","timestamp":1407243345000},"page":"1769-1778","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":11,"title":["Levels of circulating anti-muscarinic and anti-adrenergic antibodies and their effect on cardiac arrhythmias and dysautonomia in murine models of Chagas disease"],"prefix":"10.1017","volume":"141","author":[{"given":"ANISSA","family":"DALIRY","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ISABELA RESENDE","family":"PEREIRA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PEDRO PAULO","family":"PEREIRA-JUNIOR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ISALIRA PEROBA","family":"RAMOS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GLAUCIA","family":"VILAR-PEREIRA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAQUEL RANGEL","family":"SILVARES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOSELI","family":"LANNES-VIEIRA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANT\u00d4NIO CARLOS","family":"CAMPOS DE CARVALHO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,8,5]]},"reference":[{"key":"S0031182014001097_ref47","unstructured":"World Health Organization (2010). 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