{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:43:09Z","timestamp":1780087389978,"version":"3.54.0"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T00:00:00Z","timestamp":1414540800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n\t  <jats:p>MicroRNA-132 (miR-132) has been demonstrated to affect multiple neuronal functions and its dysregulation is linked to several neurological disorders. We previously showed that acute <jats:italic>Toxoplasma gondii<\/jats:italic> infection induces miR-132 expression both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. To investigate the impact of chronic infection on miR-132, we infected mice with <jats:italic>T. gondii<\/jats:italic> PRU strain and performed assessment 5 months later in six brain regions (cortex, hypothalamus, striatum, cerebellum, olfactory bulb and hippocampus) by qPCR. We found that while acute infection of <jats:italic>T. gondii<\/jats:italic> increases the expression of miR-132, chronic infection has the opposite effect. The effect varied amongst different regions of the brain and presented in a sex-dependent manner, with females exhibiting more susceptibility than males. MiR-132 and brain-derived neurotrophic factor (BDNF, an inducer of miR-132) were not co-varies in the brain areas of infected mice. <jats:italic>T. gondii<\/jats:italic> DNA\/RNA was found in all tested brain regions and a selective tropism towards the hippocampus, based on bradyzoite density, was observed in both males and females. However, the expressions of miR-132 or BDNF were poorly reflected by the density of <jats:italic>T. gondii<\/jats:italic> in brain areas. Our findings highlight the importance of investigating the miR-132-mediated neuronal function in mice infected with <jats:italic>T. gondii<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s003118201400167x","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T07:01:54Z","timestamp":1414566114000},"page":"623-632","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":31,"title":["Chronic infection of <i>Toxoplasma gondii<\/i> downregulates miR-132 expression in multiple brain regions in a sex-dependent manner"],"prefix":"10.1017","volume":"142","author":[{"given":"YE","family":"LI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GEETHA","family":"KANNAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MIKHAIL 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