{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:43:44Z","timestamp":1789177424196,"version":"build-2803163510"},"reference-count":45,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T00:00:00Z","timestamp":1424822400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Cystic echinococcosis is a chronic infectious disease that results from a host\/parasite interaction. Vaccination with ferritin derived from <jats:italic>Echinococcus granulosus<\/jats:italic> is a potential preventative treatment. To understand whether ferritin is capable of inducing a host immune response, we investigated the response of dendritic cells (DCs) to both recombinant ferritin protein and the hydatid fluid (HF) of <jats:italic>E. granulosus.<\/jats:italic> We evaluated the immunomodulatory potential of these antigens by performing, immunocytochemistry, electron microscopy and <jats:italic>in vivo<\/jats:italic> imaging of monocyte-derived murine DCs. During antigen stimulation of DCs, ferritin cause DCs maturation and induced higher levels of surface marker expression and activated T-cell proliferation and migration. On contrary, HF failed to induce surface marker expression and to stimulate T-cell proliferation. In response to HF, DCs produced interleukin-6 (IL-6), but no IL-12 and IL-10. DCs stimulated with ferritin produced high levels of cytokines. Overall, HF appears to induce host immunosuppression in order to ensure parasite survival via inhibits DC maturation and promotes Th2-dependent secretion of cytokines. Although ferritin also promoted DC maturation and cytokine release, it also activates CD4<jats:sup>+<\/jats:sup>T-cell proliferation, but regard of the mechanism of the Eg.ferritin induce host to eradicate <jats:italic>E. granulosus<\/jats:italic> were not clear.<\/jats:p>","DOI":"10.1017\/s0031182014002005","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T02:37:02Z","timestamp":1424831822000},"page":"879-889","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":17,"title":["Different protein of <i>Echinococcus granulosus<\/i> stimulates dendritic induced immune 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