{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:11:03Z","timestamp":1789852263354,"version":"4.0.1"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T00:00:00Z","timestamp":1425427200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Emergence of malaria parasites resistant to artemisinin necessitates the need for development of new antimalarial therapies. Ciprofloxacin (CFX) a second generation quinolone antibiotic possesses some antimalarial activities. We investigated the <jats:italic>in vivo<\/jats:italic> antimalarial activities of CFX in combination with amodiaquine in mice infected with chloroquine-resistant <jats:italic>Plasmodium berghei<\/jats:italic> ANKA. Animals were treated orally with 80 or 160 mg kg<jats:sup>\u22121<\/jats:sup> body weight of CFX alone given twice daily or in combination with amodiaquine (AQ) 10 mg kg<jats:sup>\u22121<\/jats:sup> body weight. Parasitological activity and survival of the animals were assessed over 21 days. Peak parasitaemia in the untreated control group was 72\u00b751%. Treatment with AQ alone resulted in clearance of parasitaemia by day 4 while treatment with CFX 80 and 160 mg kg<jats:sup>\u22121<\/jats:sup> alone suppressed parasitaemia by 13\u00b794\u201354\u00b764% and 35\u00b76\u201392\u00b77%, respectively. However, the combination of CFX with AQ significantly enhanced response of infection in the animals to treatment (<jats:italic>P<\/jats:italic> &lt; 0\u00b705) resulting in complete resolution of parasitaemia throughout follow up period with CFX 160 mg kg<jats:sup>\u22121<\/jats:sup>, delayed recrudescence time with CFX 80 mg kg<jats:sup>\u22121<\/jats:sup> and significant increase in survival rate of the animals. The results demonstrate beneficial interaction between AQ and CFX which may provide a clinically relevant antimalarial\/antibiotic therapeutic option in the management of malaria.<\/jats:p>","DOI":"10.1017\/s0031182015000062","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T03:56:31Z","timestamp":1425441391000},"page":"849-854","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Amodiaquine\u2013Ciprofloxacin: a potential combination therapy against drug resistant malaria"],"prefix":"10.1017","volume":"142","author":[{"given":"Y. F.","family":"FALAJIKI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"AKINOLA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. 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