{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:06:28Z","timestamp":1778882788575,"version":"3.51.4"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Skin schistosomula can be prepared by collecting them after isolated mouse skin have been penetrated by cercariae<jats:italic>in vitro<\/jats:italic>. The schistosomula can also migrate out of isolated mouse skin penetrated by cercariae<jats:italic>in vitro<\/jats:italic>and from mouse skin penetrated by cercariae<jats:italic>in vivo<\/jats:italic>. Schistosomula can also be produced from cercariae applied through a syringe or in a vortex. When certain surface properties of the different forms of schistosomula were compared, those migrating from mouse skin penetrated by cercariae<jats:italic>in vivo<\/jats:italic>or<jats:italic>in vitro<\/jats:italic>had greatly increased permeability to membrane impermeant molecules such as Lucifer yellow and high molecular weight dextrans. These migrating forms also possessed surfaces which showed greatly enhanced uptake into internal membrane vesicles of the dye FM 143, a marker for endocytosis. This greatly enhanced activity and permeability of the surfaces of tissue migrating schistosomula is likely to be of great importance in the adaptation to the new host.<\/jats:p>","DOI":"10.1017\/s0031182015000335","type":"journal-article","created":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T07:23:39Z","timestamp":1433143419000},"page":"1143-1151","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["The skin migratory stage of the schistosomulum of<i>Schistosoma mansoni<\/i>has a surface showing greater permeability and activity in membrane internalisation than other forms of skin or mechanical schistosomula"],"prefix":"10.1017","volume":"142","author":[{"given":"WANDER","family":"DE JESUS JEREMIAS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOSE RENAN","family":"DA CUNHA 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