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Genome annotations can now be used to help interpret fine ultrastructure and cell biology, and guide new studies to describe a variety of alveolate life strategies, such as symbiosis or free living, predation, and obligate intracellular parasitism, as well to provide foundations to dissect the evolutionary transitions between these niches. This review focuses on the attempt to identify extracellular proteins which might mediate the physical interface of cell\u2013cell interactions within the above life strategies, aided by annotation of the repertoires of predicted surface and secreted proteins encoded within alveolate genomes. In particular, we discuss what descriptions of the predicted extracellular proteomes reveal regarding a hypothetical last common ancestor of a pre-apicomplexan alveolate \u2013 guided by ultrastructure, life strategies and phylogenetic relationships \u2013 in an attempt to understand the evolution of obligate parasitism in apicomplexans.<\/jats:p>","DOI":"10.1017\/s0031182015001213","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T08:31:52Z","timestamp":1448008312000},"page":"1-17","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":23,"title":["Diversity of extracellular proteins during the transition from the \u2018proto-apicomplexan\u2019 alveolates to the apicomplexan obligate parasites"],"prefix":"10.1017","volume":"143","author":[{"given":"THOMAS 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