{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T03:40:55Z","timestamp":1692157255599},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T00:00:00Z","timestamp":1449532800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Human lymphatic filariasis (LF) is a major cause of disability globally. The success of global elimination programmes for LF depends upon effectiveness of tools for diagnosis and treatment. In this study on stage-specific antigen detection in brugian filariasis, L3, adult worm (AW) and microfilarial antigenaemia were detected in around 90\u201395% of microfilariae carriers (MF group), 50\u201370% of adenolymphangitis (ADL) patients, 10\u201325% of chronic pathology (CP) patients and 10\u201315% of endemic normal (EN) controls. The sensitivity of the circulating filarial antigen (CFA) detection in serum samples from MF group was up to 95%. In sera from ADL patients, unexpectedly, less antigen reactivity was observed. In CP group all the CFA positive individuals were from CP grade I and II only and none from grade III or IV, suggesting that with chronicity the AWs lose fecundity and start to disintegrate and die. Amongst EN subject, 10\u201315% had CFA indicating that few of them harbour filarial AWs, thus they might not be truly immune as has been conventionally believed. The specificity for antigen detection was 100% when tested with sera from various other protozoan and non-filarial helminthic infections.<\/jats:p>","DOI":"10.1017\/s0031182015001675","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T13:49:44Z","timestamp":1449668984000},"page":"350-357","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Circulating filarial antigen detection in brugian filariasis"],"prefix":"10.1017","volume":"143","author":[{"given":"PRAVEEN KUMAR","family":"TRIPATHI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAMESH CHANDER","family":"MAHAJAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NANCY","family":"MALLA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ABHISHEK","family":"MEWARA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHAILJA MISRA","family":"BHATTACHARYA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RANGANATHA KRISHNA","family":"SHENOY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAKESH","family":"SEHGAL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,12,8]]},"reference":[{"key":"S0031182015001675_ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.1996.tb00123.x"},{"key":"S0031182015001675_ref24","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2000.62.502"},{"key":"S0031182015001675_ref4","doi-asserted-by":"publisher","DOI":"10.1080\/01971529008055043"},{"key":"S0031182015001675_ref20","first-page":"32","volume-title":"Gelimmuno-diffusion Techniques in Research and Laboratory Medicine","author":"Parulekar","year":"1984"},{"key":"S0031182015001675_ref7","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.4049\/jimmunol.134.2.1172","article-title":"A monoclonal antibody based immuno-radiometric assay for detection of circulating antigen in bancroftian filariasis","volume":"134","author":"Forsyth","year":"1985","journal-title":"Journal of Immunology"},{"key":"S0031182015001675_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(76)90163-2"},{"key":"S0031182015001675_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(93)90277-W"},{"key":"S0031182015001675_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2006.12.001"},{"key":"S0031182015001675_ref19","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2883-6-9"},{"key":"S0031182015001675_ref31","unstructured":"World Health Organization (2014). 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Progress Report 2000\u20132009 and Strategic Plan 2010\u20132020 of the Global Programme to Eliminate Lymphatic Filariasis: Halfway Towards Eliminating Lymphatic Filariasis. WHO\/HTM\/NTD\/PCT\/2010.6. 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