{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:07:49Z","timestamp":1780668469037,"version":"3.54.1"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T00:00:00Z","timestamp":1450828800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The rational search of novel bioactive molecules against pathogens with immunomodulatory activity is presently one of the most significant approaches to discover and design new therapeutic agents for effective control of infectious diseases, such as the infection caused by <jats:italic>Leishmania<\/jats:italic> parasites. In the present study, we evaluated the therapeutic efficacy of the recently characterized immunomodulatory compound 11<jats:italic>\u03b1<\/jats:italic>,19<jats:italic>\u03b2<\/jats:italic>-dihydroxy-7-acetoxy-7-deoxoichangin, a <jats:italic>seco<\/jats:italic>-limonoid derived from the bark of <jats:italic>Raputia heptaphylla<\/jats:italic> (Pittier) using: (1) peritoneal macrophages and (2) <jats:italic>Mesocricetus auratus<\/jats:italic> hamsters infected with <jats:italic>Leishmania<\/jats:italic> (<jats:italic>V.<\/jats:italic>) <jats:italic>panamensis<\/jats:italic> and <jats:italic>Leishmania<\/jats:italic> (<jats:italic>L.<\/jats:italic>) <jats:italic>amazonensis<\/jats:italic>. We observed the ability of this <jats:italic>seco<\/jats:italic>-limonoid to induce the effective control of the parasite either <jats:italic>in vitro<\/jats:italic> [determining an effective concentration 50 (EC<jats:sub>50<\/jats:sub>) of 59 <jats:italic>\u00b5<\/jats:italic><jats:sc>m<\/jats:sc> at the infection model] and <jats:italic>in vivo<\/jats:italic> (inducing clinical improvement or even cure in infected animals treated compared with the groups of animals treated with vehicle solution or meglumine antimoniate).<\/jats:p>","DOI":"10.1017\/s0031182015001717","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T10:59:57Z","timestamp":1450868397000},"page":"289-299","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["<i>Seco-limonoid<\/i> derived from <i>Raputia heptaphylla<\/i> promotes the control of cutaneous leishmaniasis in hamsters (<i>Mesocricetus auratus<\/i>)"],"prefix":"10.1017","volume":"143","author":[{"given":"DIANA","family":"GRANADOS-FALLA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANGELA","family":"GOMEZ-GALINDO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALEJANDRO","family":"DAZA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SARA","family":"ROBLEDO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CARLOS","family":"COY-BARRERA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LUIS","family":"CUCA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GABRIELA","family":"DELGADO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,12,23]]},"reference":[{"key":"S0031182015001717_ref32","volume-title":"Control 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