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In this study, we have investigated the<jats:italic>in vitro<\/jats:italic>anthelmintic effect of the leaves of<jats:italic>Terminalia catappa<\/jats:italic>L. crude extract (TcCE) and albendazole (ABZ) on adult<jats:italic>Fischoederius cobboldi<\/jats:italic>after incubating the flukes in RPMI-1640 medium containing the TcCE at various doses and times. The TcCE-treated flukes at all dosages exhibited rapid decrease of motility, and the relative motility (RM) values were decreased sharply from start to 3 h. Worms were killed after 6 and 12 h of treatment with 1000, 1500 and 2000<jats:italic>\u00b5<\/jats:italic>g mL<jats:sup>\u22121<\/jats:sup>as well as 500<jats:italic>\u00b5<\/jats:italic>g mL<jats:sup>\u22121<\/jats:sup>of TcCE, respectively. By light microscopy examination, the flukes exhibited the earliest alteration in a limited area of the tegument. At scanning electron microscopy level, the flukes\u2019 tegument showed similar sequence of morphological alterations after treatment with ABZ and TcCE that consisted of swelling of ridges and folds, followed by blebbing and rupturing of the blebs, leading to the erosion, lesion and disruption of the tegument. Hence,<jats:italic>in vivo<\/jats:italic>studies should be performed to examine whether the TcCE may serve as a powerful anthelmintic drug for treatment of paramphistomosis.<\/jats:p>","DOI":"10.1017\/s0031182015001833","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T05:58:36Z","timestamp":1454306316000},"page":"421-433","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":16,"title":["The anthelmintic effects of the ethanol extract of<i>Terminalia catappa<\/i>L. leaves against the ruminant gut parasite,<i>Fischoederius 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