{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T09:43:24Z","timestamp":1776505404185,"version":"3.51.2"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T00:00:00Z","timestamp":1466121600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Synthesized lipophilic tyrosyl ester derivatives with increasing lipophilicity were effective against <jats:italic>Leishmania<\/jats:italic> (<jats:italic>L.<\/jats:italic>) <jats:italic>major<\/jats:italic> and <jats:italic>Leishmania infantum<\/jats:italic> species <jats:italic>in vitro<\/jats:italic>. These findings prompted us to test <jats:italic>in vivo<\/jats:italic> leishmanicidal properties of these molecules and their potential effect on the modulation of immune responses. The experimental BALB\/c model of cutaneous leishmaniasis was used in this study. Mice were infected with <jats:italic>L. major<\/jats:italic> parasites and treated with three <jats:italic>in vitro<\/jats:italic> active tyrosyl esters derivatives.<\/jats:p><jats:p>Among these tested tyrosylcaprate (TyC) compounds, only TyC<jats:sub>10<\/jats:sub> exhibited an <jats:italic>in vivo<\/jats:italic> anti-leishmanial activity, when injected sub-cutaneously (s.c.). TyC<jats:sub>10<\/jats:sub> treatment of <jats:italic>L. major<\/jats:italic>-infected BALB\/c mice resulted in a decrease of lesion development and parasite load. TyC<jats:sub>10<\/jats:sub> s.c. treatment of non-infected mice induced an imbalance in interferon <jats:italic>\u03b3<\/jats:italic>\/interleukin 4 (IFN-<jats:italic>\u03b3<\/jats:italic>\/IL-4) ratio cytokines towards a Th1 response. Our results indicate that TyC<jats:sub>10<\/jats:sub> s.c. treatment improves lesions\u2019 healing and parasite clearance and may act on the cytokine balance towards a Th1 protective response by decreasing IL-4 and increasing IFN-<jats:italic>\u03b3<\/jats:italic> transcripts. TyC<jats:sub>10<\/jats:sub> is worthy of further investigation to uncover its mechanism of action that could lead to consider this molecule as a potential drug candidate.<\/jats:p>","DOI":"10.1017\/s0031182016001086","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T06:18:30Z","timestamp":1466144310000},"page":"1615-1621","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Treatment with synthetic lipophilic tyrosyl ester controls <i>Leishmania major<\/i> infection by reducing parasite load in BALB\/c mice"],"prefix":"10.1017","volume":"143","author":[{"given":"RABIAA 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