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The recently sequenced genomes of four<jats:italic>Strongyloides<\/jats:italic>species, gastrointestinal parasites of humans and other animals, alongside transcriptomic and proteomic analysis of free-living and parasitic stages of their life cycles have revealed a number of protein families with a putative role in their parasitism. Many of these protein families have also been associated with parasitism in other parasitic nematode species, suggesting that these proteins may play a fundamental role in nematode parasitism more generally. Here, we review key protein families that have a putative role in<jats:italic>Strongyloides<\/jats:italic>\u2019 parasitism \u2013 acetylcholinesterases, astacins, aspartic proteases, prolyl oligopeptidases, proteinase inhibitors (trypsin inhibitors and cystatins), SCP\/TAPS and transthyretin-like proteins \u2013 and the evidence for their key, yet diverse, roles in the parasitic lifestyle.<\/jats:p>","DOI":"10.1017\/s0031182016001554","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T10:07:01Z","timestamp":1473761221000},"page":"343-358","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":31,"title":["The genome of<i>Strongyloides<\/i>spp. gives insights into protein families with a putative role in nematode parasitism"],"prefix":"10.1017","volume":"144","author":[{"given":"VICKY 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