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Elucidating the mechanisms of both protective and harmful immune responses is complex, and often relies of the use of animal models. In any immune response, leucocyte trafficking to the site of infection, or inflammation, is paramount, and this involves the production of chemokines, small chemotactic cytokines of approximately 8\u201310 kDa in size, which bind to specific chemokine receptors to induce leucocyte movement. Herein, the scientific literature investigating the role of chemokines in the propagation of immune responses against key protist infections will be reviewed, focussing on<jats:italic>Plasmodium<\/jats:italic>species,<jats:italic>Toxoplasma gondii, Leishmania<\/jats:italic>species and<jats:italic>Cryptosporidium<\/jats:italic>species. Interestingly, many studies find that chemokines can in fact, promote parasite survival in the host, by drawing in leucocytes for spread and further replication. Recent developments in drug targeting against chemokine receptors highlights the need for further understanding of the role played by these proteins and their receptors in many different diseases.<\/jats:p>","DOI":"10.1017\/s0031182016001694","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T06:34:15Z","timestamp":1475735655000},"page":"1890-1901","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":16,"title":["The role of chemokines and their receptors during protist parasite infections"],"prefix":"10.1017","volume":"143","author":[{"given":"FIONA M.","family":"MENZIES","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"MACPHAIL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FIONA 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