{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:30:01Z","timestamp":1772465401387,"version":"3.50.1"},"reference-count":46,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T00:00:00Z","timestamp":1484870400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The aim of this study was to evaluate the oxidative stress in serum and liver and adenosine deaminase (ADA) activity of cattle experimentally infected by<jats:italic>Fasciola hepatica<\/jats:italic>. The group A consisted of five healthy animals (uninfected), and the group B was composed of five animals orally infected with 200 metacercariae of<jats:italic>F. hepatica.<\/jats:italic>On days 20, 40, 60 and 80 post-infection (PI) serum was collected to measure oxidative stress variables. On day 100 PI, animals were humanely euthanized and liver samples were collected. Infected animals showed lower (<jats:italic>P<\/jats:italic>&lt; 0\u00b705) seric ADA activities on days 40 and 60 PI but higher (<jats:italic>P<\/jats:italic>&lt; 0\u00b705) in the liver tissue compared with uninfected animals. Seric and hepatic reactive oxygen species (ROS) were higher (<jats:italic>P<\/jats:italic>&lt; 0\u00b705) in infected compared with uninfected animals. Hepatic thiobarbituric acid reactive substances were higher (<jats:italic>P<\/jats:italic>&lt; 0\u00b705) in infected animals. Catalase and glutathione<jats:italic>S<\/jats:italic>-transferase activities were lower in liver tissue of infected animals, while glutathione peroxidase was higher compared with uninfected (<jats:italic>P<\/jats:italic>&lt; 0\u00b705). In summary, we conclude that oxidative stress occurs in cattle experimentally infected by<jats:italic>F. hepatica<\/jats:italic>, mainly due to excessive ROS production in the course of fasciolosis, contributing to hepatic damage, and that increased in hepatic ADA activity may contribute to the inflammatory process.<\/jats:p>","DOI":"10.1017\/s0031182016002043","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T09:16:38Z","timestamp":1484903798000},"page":"520-526","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":14,"title":["Oxidative stress and changes in adenosine deaminase activity of cattle experimentally infected by<i>Fasciola hepatica<\/i>"],"prefix":"10.1017","volume":"144","author":[{"given":"ALEKSANDRO S.","family":"DA SILVA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MATHEUS D.","family":"BALDISSERA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NATHIELI B.","family":"BOTTARI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MATHEUS E.","family":"GABRIEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEANDRO A.","family":"RHODEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MANOELA M.","family":"PIVA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICARDO","family":"CHRIST","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FERNANDA A.","family":"STEDILLE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDERSON","family":"GRIS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VERA M.","family":"MORSCH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA ROSA","family":"SCHETINGER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICARDO E.","family":"MENDES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,1,20]]},"reference":[{"key":"S0031182016002043_ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.08.017"},{"key":"S0031182016002043_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2005.07.010"},{"key":"S0031182016002043_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"S0031182016002043_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2008.01.013"},{"key":"S0031182016002043_ref16","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.122.203"},{"key":"S0031182016002043_ref18","unstructured":"Giusti G. and Galanti B. 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