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Studies using this model parasite in combination with its various natural and experimental non-human primate hosts have led to important advances in vaccine development and in our understanding of malaria invasion, immunology and parasite\u2013host interactions. The adaptation to long-term<jats:italic>in vitro<\/jats:italic>continuous blood stage culture in rhesus monkey,<jats:italic>Macaca fascicularis<\/jats:italic>and human red blood cells, as well as the development of various transfection methodologies has resulted in a highly versatile experimental malaria model, further increasing the potential of what was already a very powerful model. The growing evidence that<jats:italic>P. knowlesi<\/jats:italic>is an important human zoonosis in South-East Asia has added relevance to former and future studies of this parasite species.<\/jats:p>","DOI":"10.1017\/s0031182016002286","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T02:24:41Z","timestamp":1481509481000},"page":"56-70","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":23,"title":["<i>Plasmodium knowlesi<\/i>: a relevant, versatile experimental malaria model"],"prefix":"10.1017","volume":"145","author":[{"given":"ERICA M.","family":"PASINI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANNE-MARIE","family":"ZEEMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANNEMARIE","family":"VOORBERG-VAN DER WEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CLEMENS H. 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