{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:16:47Z","timestamp":1781090207191,"version":"3.54.1"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Ocular toxoplasmosis (OT) caused by<jats:italic>Toxoplasma gondii<\/jats:italic>is a major cause of infectious uveitis, however little is known about its immunopathological mechanism. Susceptible C57BL\/6 (B6) and resistant BALB\/c mice were intravitreally infected with 500 tachyzoites of the RH strain of<jats:italic>T. gondii<\/jats:italic>. B6 mice showed more severe ocular pathology and higher parasite loads in the eyes. The levels of galectin (Gal)-9 and its receptors (Tim-3 and CD137), interferon (IFN)-<jats:italic>\u03b3<\/jats:italic>, IL-6 and IL-10 were significantly higher in the eyes of B6 mice than those of BALB\/c mice; however, the levels of IFN-<jats:italic>\u03b1<\/jats:italic>and -<jats:italic>\u03b2<\/jats:italic>were significantly decreased in the eyes and CLNs of B6 mice but significantly increased in BALB\/c mice after infection. After blockage of galectin\u2013receptor interactions by<jats:italic>\u03b1<\/jats:italic>-lactose, neither ocular immunopathology nor parasite loads were different from those of infected BALB\/c mice without<jats:italic>\u03b1<\/jats:italic>-lactose treatment. Although the expressions of Gal-9\/receptor were significantly increased in B6 mice and Gal-1 and -3 were upregulated in both strains of mice upon ocular<jats:italic>T. gondii<\/jats:italic>infection, blockage of galectins did not change the ocular pathogenesis of genetic resistant BALB\/c mice. However, IFN-<jats:italic>\u03b1<\/jats:italic>and -<jats:italic>\u03b2<\/jats:italic>were differently expressed in B6 and BALB\/c mice, suggesting that type I IFNs may play a protective role in experimental OT.<\/jats:p>","DOI":"10.1017\/s0031182017000270","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T08:51:01Z","timestamp":1489049461000},"page":"1064-1072","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Galectins expressed differently in genetically susceptible C57BL\/6 and resistant BALB\/c mice during acute ocular<i>Toxoplasma gondii<\/i>infection"],"prefix":"10.1017","volume":"144","author":[{"given":"S.-J.","family":"CHEN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-X.","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.-G.","family":"HUANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.-L.","family":"LU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"key":"S0031182017000270_ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00284"},{"key":"S0031182017000270_ref14","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2014.70"},{"key":"S0031182017000270_ref35","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2015.72"},{"key":"S0031182017000270_ref41","doi-asserted-by":"publisher","DOI":"10.2307\/3284069"},{"key":"S0031182017000270_ref34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130772"},{"key":"S0031182017000270_ref6","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01685-06"},{"key":"S0031182017000270_ref16","first-page":"1","article-title":"Ocular toxoplasmosis: a global reassessment. 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