{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:35:38Z","timestamp":1789749338405,"version":"4.0.1"},"reference-count":43,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T00:00:00Z","timestamp":1488931200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Echinococcus multilocularis<\/jats:italic>\n                    is a most pathogenic zoonotic tapeworm that causes devastating echinococcosis in both humans and animals. Circulating microRNAs (miRNAs) are stably existed in the serum\/plasma of mammalian hosts during helminthic infection. In this study, we compared the host-circulating miRNA expression in the sera from the\n                    <jats:italic>E. multilocularis<\/jats:italic>\n                    -infected and uninfected mice. A total of 58 host-origin serum miRNAs were differentially expressed (2 \u2a7e fold change,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0\u00b705), of which 21 were upregulated and 37 were significantly downregulated. Consistent with the sequencing data, quantitative polymerase chain reaction (PCR) results showed that the expression levels of four miRNAs were elevated gradually and one decreased gradually at the\n                    <jats:italic>E. multilocularis<\/jats:italic>\n                    infection time points. Moreover, seven of\n                    <jats:italic>E. multilocularis<\/jats:italic>\n                    specific miRNAs were identified in the sera. Real-time PCR analyses further demonstrated that only two parasite-derived miRNAs (emu-miR-10 and emu-miR-227) were specifically amplified in all the sera from mice infected with\n                    <jats:italic>E. multilocularis<\/jats:italic>\n                    . These findings will be helpful to understand the roles of miRNAs in host\u2013parasite interaction and to potentiate serum miRNAs as diagnostic targets for echinococcosis.\n                  <\/jats:p>","DOI":"10.1017\/s0031182017000300","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T02:43:06Z","timestamp":1488940986000},"page":"1079-1087","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":46,"title":["Expression profiling of circulating miRNAs in mouse serum in response to\n                    <i>Echinococcus multilocularis<\/i>\n                    infection"],"prefix":"10.1017","volume":"144","author":[{"given":"XIAOLA","family":"GUO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YADONG","family":"ZHENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,3,8]]},"reference":[{"key":"S0031182017000300_ref43","doi-asserted-by":"publisher","DOI":"10.1038\/srep25885"},{"key":"S0031182017000300_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2017.01.012"},{"key":"S0031182017000300_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.03.015"},{"key":"S0031182017000300_ref40","doi-asserted-by":"publisher","DOI":"10.4161\/rna.23716"},{"key":"S0031182017000300_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2014.03.014"},{"key":"S0031182017000300_ref38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030127"},{"key":"S0031182017000300_ref37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004069"},{"key":"S0031182017000300_ref36","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X12000685"},{"key":"S0031182017000300_ref35","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-6-154"},{"key":"S0031182017000300_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.02.145"},{"key":"S0031182017000300_ref32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000722"},{"key":"S0031182017000300_ref31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605298103"},{"key":"S0031182017000300_ref29","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.145"},{"key":"S0031182017000300_ref28","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2547-6_10"},{"key":"S0031182017000300_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm995"},{"key":"S0031182017000300_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-6-272"},{"key":"S0031182017000300_ref17","article-title":"On the presence and immunoregulatory functions of extracellular microRNAs in the trematode Fasciola hepatica","author":"Fromm","year":"2016","journal-title":"Parasite Immunology"},{"key":"S0031182017000300_ref25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804549105"},{"key":"S0031182017000300_ref23","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00005"},{"key":"S0031182017000300_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1477"},{"key":"S0031182017000300_ref5","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6488"},{"key":"S0031182017000300_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2014.02.012"},{"key":"S0031182017000300_ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-013-3550-9"},{"key":"S0031182017000300_ref9","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182013000917"},{"key":"S0031182017000300_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.02.002"},{"key":"S0031182017000300_ref14","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-9-r60"},{"key":"S0031182017000300_ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00534.x"},{"key":"S0031182017000300_ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003965"},{"key":"S0031182017000300_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-007-9331-0"},{"key":"S0031182017000300_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2015.09.003"},{"key":"S0031182017000300_ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00578"},{"key":"S0031182017000300_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2016.10.024"},{"key":"S0031182017000300_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(01)00424-1"},{"key":"S0031182017000300_ref1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05005"},{"key":"S0031182017000300_ref2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.f.209"},{"key":"S0031182017000300_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70134-2"},{"key":"S0031182017000300_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.11.010"},{"key":"S0031182017000300_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2014.12.003"},{"key":"S0031182017000300_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2015.06.002"},{"key":"S0031182017000300_ref19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002701"},{"key":"S0031182017000300_ref20","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-7-433"},{"key":"S0031182017000300_ref21","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2016023"},{"key":"S0031182017000300_ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-015-0656-1"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182017000300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T16:34:15Z","timestamp":1555518855000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182017000300\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,8]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S0031182017000300"],"URL":"https:\/\/doi.org\/10.1017\/s0031182017000300","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,8]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2017\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}