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The focus of discovery research has been on the identification of potent and selective compounds that inhibit target enzymes <jats:strike>(<\/jats:strike>or other essential molecules<jats:strike>)<\/jats:strike> or are active against the causative pathogen in phenotypic <jats:italic>in vitro<\/jats:italic> assays. Although these discovery paradigms remain an essential part of the early stages of the drug R &amp; D pathway, over the past two decades additional emphasis has been given to the challenges needed to ensure that the potential anti-infective drugs distribute to infected tissues, reach the target pathogen within the host cell and exert the appropriate pharmacodynamic effect at these sites. This review will focus on how these challenges are being met in relation to <jats:italic>Leishmania<\/jats:italic> and the leishmaniases with lessons learned from drug R &amp; D for other intracellular pathogens.<\/jats:p>","DOI":"10.1017\/s0031182017001664","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T08:50:14Z","timestamp":1507279814000},"page":"237-247","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":16,"title":["<i>Leishmania<\/i> and other intracellular pathogens: selectivity, drug distribution and PK\u2013PD"],"prefix":"10.1017","volume":"145","author":[{"given":"SIMON L.","family":"CROFT","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,10,6]]},"reference":[{"key":"S0031182017001664_ref98","unstructured":"World Health Organization (2010). 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