{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T01:19:28Z","timestamp":1747358368348,"version":"3.37.3"},"reference-count":61,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T00:00:00Z","timestamp":1510099200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p><jats:italic>Cryptosporidium<\/jats:italic>spp. (Apicomplexa) causing cryptosporidiosis are of medical and veterinary significance. The genus<jats:italic>Cryptosporidium<\/jats:italic>has benefited from the application of what is considered a DNA-barcoding approach, even before the term \u2018DNA barcoding\u2019 was formally coined. Here, the objective to define the DNA barcode diversity of<jats:italic>Cryptosporidium<\/jats:italic>infecting mammals is reviewed and considered to be accomplished. Within the<jats:italic>Cryptosporidium<\/jats:italic>literature, the distinction between DNA barcoding and DNA taxonomy is indistinct. DNA barcoding and DNA taxonomy are examined using the latest additions to the growing spectrum of named<jats:italic>Cryptosporidium<\/jats:italic>species and within-species and between-species identity is revisited. Ease and availability of whole-genome DNA sequencing of the relatively small<jats:italic>Cryptosporidium<\/jats:italic>genome offer an initial perspective on the intra-host diversity. The opportunity emerges to apply a metagenomic approach to purified field\/clinical<jats:italic>Cryptosporidum<\/jats:italic>isolates. The outstanding question remains a reliable definition of<jats:italic>Cryptosporidium<\/jats:italic>phenotype. The complementary experimental infections and metagenome approach will need to be applied simultaneously to address<jats:italic>Cryptosporidium<\/jats:italic>phenotype with carefully chosen clinical evaluations enabling identification of virulence factors.<\/jats:p>","DOI":"10.1017\/s0031182017001809","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T05:56:55Z","timestamp":1510120615000},"page":"574-584","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["DNA barcoding 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