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The complex life cycle of <jats:italic>T. gondii<\/jats:italic> is regulated by a unique family of calcium-dependent protein kinases (CDPKs) that have become the target of intensive efforts to develop new therapeutics. In this review, we will summarize structure-based strategies, recent successes and future directions in the pursuit of specific and selective inhibitors of <jats:italic>T. gondii<\/jats:italic> CDPK1.<\/jats:p>","DOI":"10.1017\/s0031182017001901","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T08:54:23Z","timestamp":1512118463000},"page":"210-218","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":31,"title":["The calcium-dependent protein kinase 1 from <i>Toxoplasma gondii<\/i> as target for structure-based drug design"],"prefix":"10.1017","volume":"145","author":[{"given":"EMILY M.","family":"CARDEW","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTOPHE L. M. 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