{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:45:48Z","timestamp":1790779548922,"version":"4.1.0"},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A time-course study was conducted to resolve discrepancies in the literature and better define aspects of the\n                    <jats:italic>Eimeria maxima<\/jats:italic>\n                    life cycle such, as sites of development and both morphology and number of asexual stages. Broiler chickens were inoculated orally with five million\n                    <jats:italic>E. maxima<\/jats:italic>\n                    oocysts (APU1), and were necropsied at regular intervals from 12 to 120 h p.i. Small intestine tissue sections and smears were examined for developmental stages. The jejunum contained the highest numbers of developmental stages. At 12 h p.i., sporozoites were observed inside a parasitophorous vacuole (PV) in the epithelial villi and the lamina propria. By 24 h, sporozoites enclosed by a PV were observed in enterocytes of the glands of Lieberk\u00fchn. At 48 h p.i., sporozoites, elongated immature and mature schizonts, were all seen in the glands with merozoites budding off from a residual body. By 60 h, second-generation, sausage-shaped schizonts containing up to 12 merozoites were observed around a residual body in the villar tip of invaded enterocytes. At 72 and 96 h, profuse schizogony associated with third- and fourth-generation schizonts was observed throughout the villus. At 120 h, another generation (fifth) of schizonts were seen in villar tips as well as in subepithelium where gamonts and oocysts were also present; a few gamonts were in epithelium. Our finding of maximum parasitization of\n                    <jats:italic>E. maxima<\/jats:italic>\n                    in jejunum is important because this region is critical for nutrient absorption and weight gain.\n                  <\/jats:p>","DOI":"10.1017\/s0031182017002153","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T05:26:06Z","timestamp":1513229166000},"page":"1051-1058","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":37,"title":["Re-evaluation of the life cycle of\n                    <i>Eimeria maxima<\/i>\n                    Tyzzer, 1929 in chickens (\n                    <i>Gallus domesticus<\/i>\n                    )"],"prefix":"10.1017","volume":"145","author":[{"given":"J. P.","family":"Dubey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"S0031182017002153_ref5","first-page":"1","volume-title":"Protozoan Parasites of Domestic Animals and of Man","author":"Levine","year":"1973"},{"key":"S0031182017002153_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2017.01.009"},{"key":"S0031182017002153_ref3","doi-asserted-by":"publisher","DOI":"10.1637\/7615-042106R.1"},{"key":"S0031182017002153_ref8","first-page":"428","article-title":"Vergleeichende untersuchungen \u00fcber die kernverh\u00e4ltnisse und das wachstum bei coccidiomorphen unter besonderer beruckscchtig\u00fcng von Eimeria maxima","volume":"22","author":"Scholtyseck","year":"1963","journal-title":"Zeitshrift fur Parasitenkunde"},{"key":"S0031182017002153_ref1","first-page":"1660","article-title":"Penetration and development of Eimeria maxima sporozoites and the static effect of decoquinate","volume":"47","author":"Challey","year":"1968","journal-title":"Poultry Science"},{"key":"S0031182017002153_ref6","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1959.11685930"},{"key":"S0031182017002153_ref9","first-page":"269","article-title":"Coccidiosis in gallinaceous birds","volume":"10","author":"Tyzzer","year":"1929","journal-title":"American Journal of Hygiene"},{"key":"S0031182017002153_ref2","doi-asserted-by":"publisher","DOI":"10.1645\/GE-3159"},{"key":"S0031182017002153_ref7","first-page":"77","article-title":"The schizogony of Eimeria maxima in the chicken","volume":"38","author":"Millard","year":"1972","journal-title":"Zeitshrift furParasitenkunde"},{"key":"S0031182017002153_ref10","doi-asserted-by":"publisher","DOI":"10.2307\/3276360"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182017002153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,14]],"date-time":"2019-04-14T15:08:04Z","timestamp":1555254484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182017002153\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,14]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0031182017002153"],"URL":"https:\/\/doi.org\/10.1017\/s0031182017002153","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,14]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2017\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}