{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:55:34Z","timestamp":1792644934116,"version":"4.5.0"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study assessed the virulence of <jats:italic>Trypanosoma evansi<\/jats:italic>, the causative agent of camel trypanosomiasis (surra), affecting mainly camels among other hosts in Africa, Asia and South America, with high mortality and morbidity. Using Swiss white mice, we assessed virulence of 17 <jats:italic>T. evansi<\/jats:italic> isolates collected from surra endemic countries. We determined parasitaemia, live body weight, packed cell volume (PCV) and survivorship in mice, for a period of 60 days\u2019 post infection. Based on survivorship, the 17 isolates were classified into three virulence categories; low (31\u201360 days), moderate (11\u201330 days) and high (0\u201310 days). Differences in survivorship, PCV and bodyweights between categories were significant and correlated (<jats:italic>P<\/jats:italic> &lt; 0.05). Of the 10 Kenyan isolates, four were of low, five moderate and one (Type B) of high virulence. These findings suggest differential virulence between <jats:italic>T. evansi<\/jats:italic> isolates. In conclusion, these results show that the virulence of <jats:italic>T. evansi<\/jats:italic> may be region specific, the phenotype of the circulating parasite should be considered in the management of surra. There is also need to collect more isolates from other surra endemic regions to confirm this observation.<\/jats:p>","DOI":"10.1017\/s0031182017002359","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T03:45:00Z","timestamp":1516765500000},"page":"1235-1242","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":13,"title":["Differential virulence of camel <i>Trypanosoma evansi<\/i> isolates in mice"],"prefix":"10.1017","volume":"145","author":[{"given":"Christine M.","family":"Kamidi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Auma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul 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