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Because of their polymorphic nature, simple sequence repeats have been used extensively as genotypic markers to differentiate between isolates, but no global analysis of amino acid repeats in<jats:italic>Cryptosporidium<\/jats:italic>genomes has been reported. Taking advantage of several newly sequenced<jats:italic>Cryptosporidium<\/jats:italic>genomes, a comparative analysis of single-amino-acid repeats (SAARs) in seven species was undertaken. This analysis revealed a striking difference between the SAAR profile of the gastric and intestinal species which infect mammals and one species which infects birds. In average, total SAAR length in gastric species is only 25% of the cumulative SAAR length in the genome of<jats:italic>Cryptosporidium parvum<\/jats:italic>,<jats:italic>Cryptosporidium hominis<\/jats:italic>and<jats:italic>Cryptosporidium meleagridis<\/jats:italic>, species infectious to humans. The SAAR profile in the avian parasite<jats:italic>Cryptosporidium baileyi<\/jats:italic>stands out due to the presence of long asparagine repeats.<jats:italic>Cryptosporidium baileyi<\/jats:italic>proteins with repeats \u2a7e20 residues are significantly enriched in regulatory functions. As postulated for the related apicomplexan species<jats:italic>Plasmodium falciparum<\/jats:italic>, these observations suggest that<jats:italic>Cryptosporidium<\/jats:italic>SAARs evolve in response to selective pressure. The putative selective mechanisms driving SAAR evolution in<jats:italic>Cryptosporidium<\/jats:italic>species are unknown.<\/jats:p>","DOI":"10.1017\/s0031182018000112","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T05:57:06Z","timestamp":1518415026000},"page":"1151-1160","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Diverse single-amino-acid repeat profiles in the 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