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Although current treatments other than TTO and T4O are relatively effective in controlling the demodex mite population and the related symptoms, more research on the efficacy and drug delivery technology is needed in order to assess its potential as an alternative treatment with minimal side-effect profile, low toxicity and low risk of demodex resistance.<\/jats:p>","DOI":"10.1017\/s0031182018000495","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T09:05:06Z","timestamp":1524042306000},"page":"1510-1520","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":32,"title":["Can the tea tree oil (Australian native plant:<i>Melaleuca alternifolia Cheel<\/i>) be an alternative treatment for human demodicosis on skin?"],"prefix":"10.1017","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7883-5217","authenticated-orcid":false,"given":"Nelson Siu Kei","family":"Lam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7738-8272","authenticated-orcid":false,"given":"Xin Xin","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu-Kai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James CG","family":"Doery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2018,4,18]]},"reference":[{"key":"S0031182018000495_ref42","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23407.x"},{"key":"S0031182018000495_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70654-5"},{"key":"S0031182018000495_ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050639"},{"key":"S0031182018000495_ref51","doi-asserted-by":"publisher","DOI":"10.1159\/000362491"},{"key":"S0031182018000495_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2004.11.035"},{"key":"S0031182018000495_ref108","doi-asserted-by":"publisher","DOI":"10.1080\/23312025.2017.1318476"},{"key":"S0031182018000495_ref41","unstructured":"Australian Tea Tree Industry Association (2017). 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