{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T09:15:15Z","timestamp":1793438115795,"version":"4.5.0"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Northeastern China is a region of high tick abundance, multiple tick-borne pathogens and likely human infections. The spectrum of diseases caused by tick-borne pathogens has not been objectively evaluated in this region for clinical management and for comparison with other regions globally where tick-transmitted diseases are common. Based on clinical symptoms, PCR, indirect immunofluorescent assay and (or) blood smear, we identified and described tick-borne diseases from patients with recent tick bite seen at Mudanjiang Forestry Central Hospital. From May 2010 to September 2011, 42% (75\/180) of patients were diagnosed with a specific tick-borne disease, including Lyme borreliosis, tick-borne encephalitis, human granulocytic anaplasmosis, human babesiosis and spotted fever group rickettsiosis. When we compared clinical and laboratory features to identify factors that might discriminate tick-transmitted infections from those lacking that evidence, we revealed that erythema migrans and neurological manifestations were statistically significantly differently presented between those with and without documented aetiologies (<jats:italic>P<\/jats:italic>&lt; 0.001,<jats:italic>P<\/jats:italic>= 0.003). Twelve patients (6.7%, 12\/180) were co-infected with two tick-borne pathogens. We demonstrated the poor ability of clinicians to identify the specific tick-borne disease. In addition, it is necessary to develop specific laboratory assays for optimal diagnosis of tick-borne diseases.<\/jats:p>","DOI":"10.1017\/s0031182018001178","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T09:07:06Z","timestamp":1533114426000},"page":"161-167","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":13,"title":["The prevalence and clinical characteristics of tick-borne diseases at One Sentinel Hospital in Northeastern China"],"prefix":"10.1017","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5744-760X","authenticated-orcid":false,"given":"Hong-Bo","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Bing","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Chun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Bo","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Gui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Ruo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Xi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Huan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Fu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Chun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2018,8,1]]},"reference":[{"key":"S0031182018001178_ref37","doi-asserted-by":"publisher","DOI":"10.1086\/317465"},{"key":"S0031182018001178_ref38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb07335.x"},{"key":"S0031182018001178_ref36","doi-asserted-by":"publisher","DOI":"10.1086\/314663"},{"key":"S0031182018001178_ref35","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-4-17"},{"key":"S0031182018001178_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2008.05.026"},{"key":"S0031182018001178_ref32","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2008.0005"},{"key":"S0031182018001178_ref30","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.4.719-756.2005"},{"key":"S0031182018001178_ref40","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010095"},{"key":"S0031182018001178_ref25","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2008.0028"},{"key":"S0031182018001178_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)70051-4"},{"key":"S0031182018001178_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)71046-1"},{"key":"S0031182018001178_ref15","first-page":"93","article-title":"Lyme disease and human granulocytic anaplasmosis coinfection: impact of case definition on coinfection rates and illness severity","volume":"56","author":"Horowitz","year":"2013","journal-title":"Journal of Biochemistry and Molecular Biology"},{"key":"S0031182018001178_ref7","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2006.75.664"},{"key":"S0031182018001178_ref6","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.68.547"},{"key":"S0031182018001178_ref3","doi-asserted-by":"publisher","DOI":"10.1086\/320160"},{"key":"S0031182018001178_ref2","doi-asserted-by":"publisher","DOI":"10.1086\/313532"},{"key":"S0031182018001178_ref1","doi-asserted-by":"publisher","DOI":"10.1089\/153036602321653851"},{"key":"S0031182018001178_ref18","doi-asserted-by":"publisher","DOI":"10.3201\/eid2005.130995"},{"key":"S0031182018001178_ref21","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530450047031"},{"key":"S0031182018001178_ref9","first-page":"407","article-title":"Fatal cases of Rocky Mountain spotted fever in family clusters \u2013 three states, 2003","volume":"53","year":"2004","journal-title":"MMWR. 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