{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:39:34Z","timestamp":1792010374350,"version":"4.4.0"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"13","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Parasites sometimes expand their host range and cause new disease aetiologies. Genetic changes can then occur due to host-specific adaptive alterations, particularly when parasites cross between evolutionarily distant hosts. Characterizing genetic variation in<jats:italic>Cryptosporidium<\/jats:italic>from humans and other animals may have important implications for understanding disease dynamics and transmission. We analyse sequences from four loci (gp60, HSP-70, COWP and actin) representing multiple<jats:italic>Cryptosporidium<\/jats:italic>species reported in humans. We predicted low genetic diversity in species that present unusual human infections due to founder events and bottlenecks. High genetic diversity was observed in isolates from humans of<jats:italic>Cryptosporidium meleagridis, Cryptosporidium cuniculus, Cryptosporidium hominis<\/jats:italic>and<jats:italic>Cryptosporidium parvum<\/jats:italic>. A deviation of expected values of neutrality using Tajima's<jats:italic>D<\/jats:italic>was observed in<jats:italic>C. cuniculus<\/jats:italic>and<jats:italic>C. meleagridis<\/jats:italic>. The high genetic diversity in<jats:italic>C. meleagridis<\/jats:italic>and<jats:italic>C. cuniculus<\/jats:italic>did not match our expectations but deviations from neutrality indicate a recent decrease in genetic variability through a population bottleneck after an expansion event.<jats:italic>Cryptosporidium hominis<\/jats:italic>was also found with a significant Tajima's D positive value likely caused by recent population expansion of unusual genotypes in humans. These insights indicate that changes in genetic diversity can help us to understand host-parasite adaptation and evolution.<\/jats:p>","DOI":"10.1017\/s0031182020001493","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T05:39:11Z","timestamp":1597037951000},"page":"1532-1537","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":15,"title":["Comparative genetic diversity of<i>Cryptosporidium<\/i>species causing human infections"],"prefix":"10.1017","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6665-9671","authenticated-orcid":false,"given":"Juan C.","family":"Garcia-R","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray P.","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T. 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