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Thus, we demonstrated antiparasitic effects of ethanolic extracts of <jats:italic>Jatropha gossypiifolia<\/jats:italic> and <jats:italic>Piper arboreum<\/jats:italic> on cercariae and adult worms of <jats:italic>Schistosoma mansoni<\/jats:italic>. The bioassays were performed at 0\u201310 000 <jats:italic>\u03bc<\/jats:italic>g mL<jats:sup>\u22121<\/jats:sup> concentration for 0\u201372 h. Adult worms were stained with carmine to assess external and internal damage. The chemical screening was performed using high-performance liquid chromatography. <jats:italic>P. arboreum<\/jats:italic> displayed the best cercaricidal effect, with a 100% reduction in viability in just 60 min. The extract of <jats:italic>J. gossypiifolia<\/jats:italic> was more effective against adult worms, with 100% viability reduction of male and female worms after 12 and 24 h, respectively. <jats:italic>P. arboreum<\/jats:italic> and <jats:italic>J. gossypiifolia<\/jats:italic> were equally effective in inhibiting the oviposition of <jats:italic>S. mansoni<\/jats:italic> (93% reduction) and causing damage to internal and external structures in adult worms. Flavonoids were identified in both the extracts and phenolic compounds and amides only in <jats:italic>P. arboreum<\/jats:italic>. Thus, for the first time, it was proven that ethanolic extracts of <jats:italic>P. arboreum<\/jats:italic> and <jats:italic>J. gossypiifolia<\/jats:italic> leaves are biologically active against cercariae and adult worms of <jats:italic>S. mansoni in vitro<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s003118202000181x","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T01:35:23Z","timestamp":1600738523000},"page":"1689-1699","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Antiparasitic effects of ethanolic extracts of <i>Piper arboreum<\/i> and <i>Jatropha gossypiifolia<\/i> leaves on cercariae and adult worms of <i>Schistosoma mansoni<\/i>"],"prefix":"10.1017","volume":"147","author":[{"given":"Rayan Rubens","family":"da Silva Alves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Gustavo","family":"Mendes 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