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Experimental groups were formed, each of which was treated with one of the tested drugs. Infection of animals was carried out with<jats:italic>Leishmania major<\/jats:italic>promastigotes. We selected highly virulent strains of<jats:italic>L. major<\/jats:italic>culture isolated from human ulcers or rodents. Meglumine antimoniate monotherapy and doxycycline monotherapy are quite effective and do not differ by the 30th day of their use in such indicators as the average degree of local damage and the average number of<jats:italic>Leishmania<\/jats:italic>in the lesions. The main differences were recorded in terms of average body weight gain and average clinical recovery in favour of doxycycline.<jats:italic>Leishmania<\/jats:italic>in the lesion on the 60th day were completely absent in treatment with doxycycline. The experiment proved the effectiveness of doxycycline monotherapy:<jats:italic>Leishmania<\/jats:italic>in the lesions were absolutely absent by the end of the treatment.<\/jats:p>","DOI":"10.1017\/s0031182020002152","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T08:07:18Z","timestamp":1605514038000},"page":"361-365","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of doxycycline for the treatment of zoonotic cutaneous leishmaniasis<i>in vivo<\/i>"],"prefix":"10.1017","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6732-1197","authenticated-orcid":false,"given":"Iuliia K.","family":"Akulinina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iza A.","family":"Berechikidze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana N.","family":"Larina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana V.","family":"Sakharova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana Yu.","family":"Degtyarevskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Romanelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"volume-title":"Guidelines for Preclinical Studies of Drugs","year":"2012","author":"Mironov","key":"S0031182020002152_ref18"},{"key":"S0031182020002152_ref25","first-page":"1","article-title":"Recent advances and new strategies on leishmaniasis treatment","volume":"2","author":"Roatt","year":"2020","journal-title":"Applied Microbiology and Biotechnology"},{"key":"S0031182020002152_ref22","first-page":"CD004834","article-title":"Interventions for American cutaneous and mucocutaneous leishmaniasis","volume":"8","author":"Pinart","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"S0031182020002152_ref6","first-page":"874","article-title":"Doxycycline","volume":"129","author":"Bonnetblanc","year":"2002","journal-title":"Annales de Dermatologie et de V\u00e9n\u00e9r\u00e9ologie"},{"key":"S0031182020002152_ref5","first-page":"57","article-title":"Two cases of cutaneous leishmaniasis in Kharkov","volume":"3","author":"Bodnya","year":"2014","journal-title":"Dermatology and Venereology"},{"key":"S0031182020002152_ref12","first-page":"107","article-title":"The epidemiological situation of visceral leishmaniasis in the territory of the Republic of Azerbaijan in the modern period","volume":"5","author":"Jalilov","year":"2017","journal-title":"Family Medicine"},{"key":"S0031182020002152_ref28","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.4.1501"},{"key":"S0031182020002152_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-020-10846-y"},{"key":"S0031182020002152_ref27","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.12-0736"},{"key":"S0031182020002152_ref30","unstructured":"WHO (2010) Control of the leishmaniases. 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In the collection: Histology. Clinical and experimental morphology. 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