{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:17:45Z","timestamp":1792844265188,"version":"4.5.0"},"reference-count":55,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A prior systematic review on the efficacy of halofuginone (HFG) treatment to prevent or treat cryptosporidiosis in bovine calves was inconclusive. We undertook an updated synthesis and meta-analyses on key outcomes for the treatment of calves with HFG. Evaluated outcomes were oocyst shedding, diarrhoea, mortality and weight gain. Experiments had to describe results for same age animals in contemporary arms. Most doses were 100\u2013150 mcg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    day\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Results were subgrouped by study design, experiments with the lowest risk of bias and lack of industry funding. Eighteen articles were found that described 25 experiments. Most evidence came from randomized controlled trials in Europe. Significantly lower incidence of oocyst shedding, diarrhoea burden and mortality was reported when treatment started before calves were 5 days old. Most studies reported on outcomes for animals up to at least 28 days old. Publication bias was possible in all outcomes and seemed especially likely for diarrhoea outcomes. Beneficial results when HFG treatment was initiated in calves older than 5 days were also found. Prophylactic treatment to prevent cryptosporidiosis is effective in preventing multiple negative outcomes and is beneficial to calf health and will result in a reduction of environmental contamination by\n                    <jats:italic>Cryptosporidium<\/jats:italic>\n                    oocysts.\n                  <\/jats:p>","DOI":"10.1017\/s0031182020002267","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T23:41:26Z","timestamp":1606866086000},"page":"408-419","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":36,"title":["Efficacy of halofuginone products to prevent or treat cryptosporidiosis in bovine calves: a systematic review and meta-analyses"],"prefix":"10.1017","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5272-7995","authenticated-orcid":false,"given":"Julii","family":"Brainard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte C.","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5902-4136","authenticated-orcid":false,"given":"Frank","family":"Katzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Hurle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0647-8158","authenticated-orcid":false,"given":"Kevin","family":"Tyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"S0031182020002267_ref28","doi-asserted-by":"publisher","DOI":"10.1136\/vr.148.4.108"},{"key":"S0031182020002267_ref23","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-4-381"},{"key":"S0031182020002267_ref35","doi-asserted-by":"publisher","DOI":"10.17236\/sat00163"},{"key":"S0031182020002267_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(03)00006-2"},{"key":"S0031182020002267_ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2013.04.022"},{"key":"S0031182020002267_ref22","first-page":"101","article-title":"Rates and risk factors for contagious disease and mortality in young dairy heifers","volume":"205","author":"Johnson","year":"2011","journal-title":"Animal Science Reviews"},{"key":"S0031182020002267_ref25","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.790"},{"key":"S0031182020002267_ref53","first-page":"339","article-title":"Effects of prophylactic halofuginon administration during the first week of life on productivity and health of rearing calves","volume":"67","author":"Wiedemann","year":"2012","journal-title":"Tierarztliche Umschau"},{"key":"S0031182020002267_ref16","doi-asserted-by":"publisher","DOI":"10.3138\/jvme.1111.109R"},{"key":"S0031182020002267_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2013.04.029"},{"key":"S0031182020002267_ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006295"},{"key":"S0031182020002267_ref31","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.8.1498"},{"key":"S0031182020002267_ref4","doi-asserted-by":"publisher","DOI":"10.20944\/preprints202007.0743.v1"},{"key":"S0031182020002267_ref50","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b00452"},{"key":"S0031182020002267_ref1","first-page":"100400","article-title":"A single-cohort study of Cryptosporidium bovis and Cryptosporidium ryanae in dairy cattle from birth to calving","volume":"20","author":"\u00c5berg","year":"2020","journal-title":"Veterinary Parasitology: Regional Studies and Reports"},{"key":"S0031182020002267_ref46","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182019000829"},{"key":"S0031182020002267_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.05.007"},{"key":"S0031182020002267_ref20","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(05)72854-X"},{"key":"S0031182020002267_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2005.07.009"},{"key":"S0031182020002267_ref45","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-017-0447-0"},{"key":"S0031182020002267_ref36","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.61.10.4440-4445.1993"},{"key":"S0031182020002267_ref32","doi-asserted-by":"publisher","DOI":"10.1186\/s13028-014-0075-x"},{"key":"S0031182020002267_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2020.03.002"},{"key":"S0031182020002267_ref12","unstructured":"European Medicines Agency (2007) HALOCUR: EPAR Summary for the Public. 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