{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T02:22:41Z","timestamp":1776046961928,"version":"3.50.1"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:fig position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mime-subtype=\"png\" mimetype=\"image\" xlink:href=\"S0031182021000317_figAb.png\"\/><\/jats:fig><\/jats:p>","DOI":"10.1017\/s0031182021000317","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T06:20:43Z","timestamp":1613542843000},"page":"1143-1150","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":11,"title":["Effects of trypanocidal drugs on DNA synthesis: new insights into melarsoprol growth inhibition"],"prefix":"10.1017","volume":"148","author":[{"given":"Stephen","family":"Larson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"McKenzie","family":"Carter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5995-9329","authenticated-orcid":false,"given":"Galadriel","family":"Hovel-Miner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"S0031182021000317_ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nature10771"},{"key":"S0031182021000317_ref35","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01788-12"},{"key":"S0031182021000317_ref13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010352200"},{"key":"S0031182021000317_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2017.02.001"},{"key":"S0031182021000317_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2017.08.002"},{"key":"S0031182021000317_ref22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.51.34098"},{"key":"S0031182021000317_ref27","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-811-0:301"},{"key":"S0031182021000317_ref25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01721.x"},{"key":"S0031182021000317_ref33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303035200"},{"key":"S0031182021000317_ref30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02831.x"},{"key":"S0031182021000317_ref5","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02754-13"},{"key":"S0031182021000317_ref14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097600"},{"key":"S0031182021000317_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn104"},{"key":"S0031182021000317_ref2","first-page":"430","article-title":"Challenges in drug discovery targeting TriTryp diseases with an emphasis on leishmaniasis","volume":"8","author":"Alc\u00e2ntara","year":"2018","journal-title":"International Journal for Parasitology: Drugs and Drug Resistance"},{"key":"S0031182021000317_ref23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306306200"},{"key":"S0031182021000317_ref31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006980"},{"key":"S0031182021000317_ref36","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv376"},{"key":"S0031182021000317_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2018.04.002"},{"key":"S0031182021000317_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(99)00002-X"},{"key":"S0031182021000317_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-1051-6"},{"key":"S0031182021000317_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2016.08.016"},{"key":"S0031182021000317_ref29","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25040793"},{"key":"S0031182021000317_ref15","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2019.55.11.3068795"},{"key":"S0031182021000317_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2007.02.008"},{"key":"S0031182021000317_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2010.11.010"},{"key":"S0031182021000317_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/jeu.12408"},{"key":"S0031182021000317_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(94)90402-2"},{"key":"S0031182021000317_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2007.01.017"},{"key":"S0031182021000317_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(00)00477-9"},{"key":"S0031182021000317_ref17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.8.2607"},{"key":"S0031182021000317_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30612-7"},{"key":"S0031182021000317_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2008.03.006"},{"key":"S0031182021000317_ref37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006679"},{"key":"S0031182021000317_ref32","first-page":"1","article-title":"Nuclear DNA replication and repair in parasites of the genus Leishmania: exploiting differences to develop innovative therapeutic approaches","volume":"43","author":"Uzcanga","year":"2016","journal-title":"Critical Reviews in Microbiology"},{"key":"S0031182021000317_ref8","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00769-20"},{"key":"S0031182021000317_ref28","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200900097"},{"key":"S0031182021000317_ref3","doi-asserted-by":"publisher","DOI":"10.1101\/gr.115089.110"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182021000317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T09:27:50Z","timestamp":1626773270000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182021000317\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0031182021000317"],"URL":"https:\/\/doi.org\/10.1017\/s0031182021000317","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,17]]},"assertion":[{"value":"Copyright \u00a9 The Author(s) 2021. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is included and the original work is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}