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Children typically harbour the largest burden of<jats:italic>T. trichiura<\/jats:italic>and they are usually co-infected with other soil-transmitted helminth (STH), including<jats:italic>Ascaris lumbricoides<\/jats:italic>and hookworm. The consequences of trichuriasis, such as malnutrition and physical and cognitive growth restriction, lead to a massive health burden in endemic regions. Despite the implementation of mass drug administration of anthelminthic treatment to school-age children,<jats:italic>T. trichiura<\/jats:italic>infection remains challenging to control due to the low efficacy of current drugs as well as high rates of post-treatment re-infection. Thus, the development of a vaccine that would induce protective immunity and reduce infection rate or community faecal egg output is essential. Hurdles for human whipworm vaccine development include the lack of suitable vaccine antigen targets and animal models for human<jats:italic>T. trichiura<\/jats:italic>infection. Instead, rodent whipworm<jats:italic>T. muris<\/jats:italic>infected mouse models serve as a major surrogate for testing immunogenicity and efficacy of vaccine candidates. In this review, we summarize recent advances in animal models for<jats:italic>T. trichiura<\/jats:italic>antigen discovery and testing of vaccine candidates, while providing an overall view of the current status of<jats:italic>T. trichiura<\/jats:italic>vaccine development.<\/jats:p>","DOI":"10.1017\/s0031182021000500","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T03:52:15Z","timestamp":1616557935000},"page":"1783-1794","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Advances in vaccine development for human 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