{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:24:03Z","timestamp":1762543443214,"version":"3.40.5"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Echinococcus shiquicus<\/jats:italic> is currently limited to the Qinghai\u2013Tibet plateau, a large mountainous region in China. Although the zoonotic potential remains unknown, progress is being made on the distribution and intermediate host range. In this study, we report <jats:italic>E. shiquicus<\/jats:italic> within Gansu and Qinghai provinces in regions located not only around the central areas but also the southeast edge of the plateau and describe their genetic relationship with previous isolates from the plateau. From 1879 plateau pikas examined, 2.39% (95% CI 1.79\u20133.18) were infected with <jats:italic>E. shiquicus.<\/jats:italic> The highest prevalence of 10.26% (4.06\u201323.58) was recorded in Makehe town, Qinghai province. Overall the prevalence was marginally higher in Qinghai (2.5%, CI 1.82\u20133.43) than in Gansu (2%, CI 1.02\u20133.89). The <jats:italic>cox<\/jats:italic>1 and <jats:italic>nad<\/jats:italic>1 genes demonstrated high and low haplotype and nucleotide diversities, respectively. The median-joining network constructed by the <jats:italic>cox<\/jats:italic>1\u2013<jats:italic>nad<\/jats:italic>1 gene sequences demonstrated a star-like configuration with a median vector (unsampled haplotype) occupying the centre of the network. No peculiar distinction or common haplotype was observed in isolates originating from the different provinces. The presence of <jats:italic>E. shiquicus<\/jats:italic> in regions of the southeast and northeast edges of the Qinghai\u2013Tibet plateau and high genetic variation warrants more investigation into the haplotype distribution and genetic polymorphism by exploring more informative DNA regions of the mitochondrial genome to provide epidemiologically useful insight into the population structure of <jats:italic>E. shiquicus<\/jats:italic> across the plateau and its axis.<\/jats:p>","DOI":"10.1017\/s0031182021000512","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T03:52:28Z","timestamp":1616557948000},"page":"879-886","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["<i>Echinococcus shiquicus<\/i> in Qinghai\u2013Tibet plateau: population structure and confirmation of additional endemic 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