{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:46:27Z","timestamp":1779122787332,"version":"3.51.4"},"reference-count":148,"publisher":"Cambridge University Press (CUP)","issue":"14","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human ascariasis is the most common and prevalent neglected tropical disease and is estimated that ~819 million people are infected around the globe, accounting for 0.861 million years of disability-adjusted life years in 2017. Even with the existence of highly effective drugs, the constant presence of infective parasite eggs in the environment contribute to a high reinfection rate after treatment. Due to its high prevalence and broad geographic distribution <jats:italic>Ascaris<\/jats:italic> infection is associated with a variety of co-morbidities and co-infections. Here, we provide data from both experimental models and humans studies that illustrate how complex is the interaction of <jats:italic>Ascaris<\/jats:italic> with the host immune system, especially, in the context of reinfections, co-infections and associated co-morbidities.<\/jats:p>","DOI":"10.1017\/s0031182021000627","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T12:57:31Z","timestamp":1618232251000},"page":"1764-1773","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":9,"title":["Immunological underpinnings of <i>Ascaris<\/i> infection, reinfection and co-infection and their associated co-morbidities"],"prefix":"10.1017","volume":"148","author":[{"given":"Luisa","family":"Magalh\u00e3es","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise S.","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro H.","family":"Gazzinelli-Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricio M. S.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Kraemer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Clara","family":"Gazzinelli-Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flaviane","family":"Vieira-Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo T.","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3510-4590","authenticated-orcid":false,"given":"Lilian L.","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"S0031182021000627_ref122","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2006.44.2.163"},{"key":"S0031182021000627_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68653-4"},{"key":"S0031182021000627_ref56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2006.00901.x"},{"key":"S0031182021000627_ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2003.10.009"},{"key":"S0031182021000627_ref100","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2007.07.008"},{"key":"S0031182021000627_ref134","doi-asserted-by":"publisher","DOI":"10.1159\/000049519"},{"key":"S0031182021000627_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.04.004"},{"key":"S0031182021000627_ref95","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2002)088[0055:IHIAAW]2.0.CO;2"},{"key":"S0031182021000627_ref47","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31460-X"},{"key":"S0031182021000627_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(97)01144-7"},{"key":"S0031182021000627_ref67","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2015.06.008"},{"key":"S0031182021000627_ref118","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.12.1147"},{"key":"S0031182021000627_ref97","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009005976"},{"key":"S0031182021000627_ref121","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2008.03.006"},{"key":"S0031182021000627_ref140","unstructured":"WHO (2011) Helminth control in school-age children Second edition A guide for managers of control programmes."},{"key":"S0031182021000627_ref60","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00270"},{"key":"S0031182021000627_ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.10.051"},{"key":"S0031182021000627_ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0330-5"},{"key":"S0031182021000627_ref144","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092121"},{"key":"S0031182021000627_ref114","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0406OC"},{"key":"S0031182021000627_ref78","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(89)90165-9"},{"key":"S0031182021000627_ref77","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01822-05"},{"key":"S0031182021000627_ref109","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-015-0962-7"},{"key":"S0031182021000627_ref125","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2015.07.003"},{"key":"S0031182021000627_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(85)90114-0"},{"key":"S0031182021000627_ref111","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1996.0034"},{"key":"S0031182021000627_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.09.005"},{"key":"S0031182021000627_ref90","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507442112"},{"key":"S0031182021000627_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02084.x"},{"key":"S0031182021000627_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2011.01288.x"},{"key":"S0031182021000627_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2010.09.012"},{"key":"S0031182021000627_ref119","article-title":"Ascaris lumbricoides coinfection reduces tissue damage by decreasing IL-6 levels without altering clinical evolution of pulmonary tuberculosis or Th1\/Th2\/Th17 cytokine profile","volume":"52:e20190315","author":"Santos","year":"2019","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"key":"S0031182021000627_ref62","doi-asserted-by":"publisher","DOI":"10.1038\/251613a0"},{"key":"S0031182021000627_ref64","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.16.1937"},{"key":"S0031182021000627_ref94","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.65.834"},{"key":"S0031182021000627_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw027"},{"key":"S0031182021000627_ref19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7325"},{"key":"S0031182021000627_ref61","doi-asserted-by":"publisher","DOI":"10.1086\/425014"},{"key":"S0031182021000627_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s40475-015-0058-7"},{"key":"S0031182021000627_ref40","doi-asserted-by":"publisher","DOI":"10.1038\/nri3476"},{"key":"S0031182021000627_ref52","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(68)90109-5"},{"key":"S0031182021000627_ref15","unstructured":"CDC (2019) CDC \u2013 Ascariasis \u2013 General Information \u2013 Frequently Asked Questions (FAQs)."},{"key":"S0031182021000627_ref129","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(82)90019-X"},{"key":"S0031182021000627_ref83","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182006000394"},{"key":"S0031182021000627_ref84","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005342"},{"key":"S0031182021000627_ref44","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02535"},{"key":"S0031182021000627_ref69","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1273rev"},{"key":"S0031182021000627_ref141","unstructured":"WHO (2015) Inversting to overcome the global impact of neglected tropical diseases."},{"key":"S0031182021000627_ref103","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.43.020192.002221"},{"key":"S0031182021000627_ref147","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.1995.33.1.37"},{"key":"S0031182021000627_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.07.005"},{"key":"S0031182021000627_ref37","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.574910"},{"key":"S0031182021000627_ref93","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2000.00284.x"},{"key":"S0031182021000627_ref45","doi-asserted-by":"publisher","DOI":"10.1172\/JCI127963"},{"key":"S0031182021000627_ref20","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010599.pub2"},{"key":"S0031182021000627_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00101-7"},{"key":"S0031182021000627_ref72","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200603-331OC"},{"key":"S0031182021000627_ref42","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600829"},{"key":"S0031182021000627_ref87","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-499"},{"key":"S0031182021000627_ref102","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006711"},{"key":"S0031182021000627_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32335-3"},{"key":"S0031182021000627_ref86","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-273"},{"key":"S0031182021000627_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32154-2"},{"key":"S0031182021000627_ref59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008628"},{"key":"S0031182021000627_ref113","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0364OC"},{"key":"S0031182021000627_ref58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2007.00979.x"},{"key":"S0031182021000627_ref75","first-page":"27","volume-title":"Methods in Molecular Biology","author":"Liu","year":"2017"},{"key":"S0031182021000627_ref99","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004382"},{"key":"S0031182021000627_ref71","first-page":"501","article-title":"A macrophage dependent factor that stimulates the proliferation of fibroblasts in vitro","volume":"84","author":"Leibovich","year":"1976","journal-title":"American Journal of Pathology"},{"key":"S0031182021000627_ref53","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2001.0903"},{"key":"S0031182021000627_ref138","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00533-18"},{"key":"S0031182021000627_ref27","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/821578"},{"key":"S0031182021000627_ref50","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/364137"},{"key":"S0031182021000627_ref136","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32830a502e"},{"key":"S0031182021000627_ref135","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-095906"},{"key":"S0031182021000627_ref74","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.011"},{"key":"S0031182021000627_ref96","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.3.1142-1148.2005"},{"key":"S0031182021000627_ref112","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4643"},{"key":"S0031182021000627_ref66","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X99000335"},{"key":"S0031182021000627_ref82","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.2.484-489.1999"},{"key":"S0031182021000627_ref51","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2002.00600.x"},{"key":"S0031182021000627_ref34","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01446.x"},{"key":"S0031182021000627_ref107","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/17.4.691"},{"key":"S0031182021000627_ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000357004"},{"key":"S0031182021000627_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.04.083"},{"key":"S0031182021000627_ref139","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.594520"},{"key":"S0031182021000627_ref76","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001582"},{"key":"S0031182021000627_ref54","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.90"},{"key":"S0031182021000627_ref146","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000182541.52971.eb"},{"key":"S0031182021000627_ref108","doi-asserted-by":"publisher","DOI":"10.1038\/ni1544"},{"key":"S0031182021000627_ref126","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-396978-1.00014-8"},{"key":"S0031182021000627_ref124","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.05.075"},{"key":"S0031182021000627_ref80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002138"},{"key":"S0031182021000627_ref120","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.8.4718"},{"key":"S0031182021000627_ref130","first-page":"2104","article-title":"An ultraviolet-attenuated egg vaccine for swine ascariasis: parameters affecting the development of protective immunity","volume":"45","author":"Urban","year":"1984","journal-title":"American Journal of Veterinary Research"},{"key":"S0031182021000627_ref110","doi-asserted-by":"publisher","DOI":"10.1038\/nri3341"},{"key":"S0031182021000627_ref123","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(03)90117-9"},{"key":"S0031182021000627_ref117","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.007"},{"key":"S0031182021000627_ref55","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3244"},{"key":"S0031182021000627_ref33","doi-asserted-by":"publisher","DOI":"10.2307\/3277198"},{"key":"S0031182021000627_ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.08.014"},{"key":"S0031182021000627_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2016.08.007"},{"key":"S0031182021000627_ref137","doi-asserted-by":"publisher","DOI":"10.1002\/0471141755.ph0546s40"},{"key":"S0031182021000627_ref88","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4307"},{"key":"S0031182021000627_ref92","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-259"},{"key":"S0031182021000627_ref5","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4070561"},{"key":"S0031182021000627_ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1461-9"},{"key":"S0031182021000627_ref26","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401638"},{"key":"S0031182021000627_ref132","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1985.03350370120036"},{"key":"S0031182021000627_ref22","doi-asserted-by":"publisher","DOI":"10.1086\/423944"},{"key":"S0031182021000627_ref98","doi-asserted-by":"publisher","DOI":"10.1645\/GE-1987.1"},{"key":"S0031182021000627_ref128","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1996.11813053"},{"key":"S0031182021000627_ref13","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2006.75.194"},{"key":"S0031182021000627_ref105","doi-asserted-by":"publisher","DOI":"10.1186\/s12948-018-0088-5"},{"key":"S0031182021000627_ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002755"},{"key":"S0031182021000627_ref106","first-page":"61S","volume-title":"Chest","author":"Raghow","year":"1991"},{"key":"S0031182021000627_ref89","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/31.8.1363"},{"key":"S0031182021000627_ref145","doi-asserted-by":"publisher","DOI":"10.1038\/nri1412"},{"key":"S0031182021000627_ref104","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-7-37"},{"key":"S0031182021000627_ref36","doi-asserted-by":"publisher","DOI":"10.1007\/BF00931733"},{"key":"S0031182021000627_ref127","first-page":"1","article-title":"Helminth antigen exposure enhances early immune control of mycobacterium tuberculosis in monocytes and macrophages","volume":"17","author":"Togarsimalemath","year":"2020","journal-title":"Journal of Innate Immunity"},{"key":"S0031182021000627_ref21","doi-asserted-by":"publisher","DOI":"10.1086\/315830"},{"key":"S0031182021000627_ref79","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2005.09.002"},{"key":"S0031182021000627_ref115","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0299OC"},{"key":"S0031182021000627_ref133","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03206-2"},{"key":"S0031182021000627_ref131","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(88)90051-3"},{"key":"S0031182021000627_ref8","volume-title":"Bleomicina: un modelo de fibrosis pulmonar","author":"Ben\u00edtez","year":"2006"},{"key":"S0031182021000627_ref29","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3083568"},{"key":"S0031182021000627_ref116","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2736"},{"key":"S0031182021000627_ref18","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2628"},{"key":"S0031182021000627_ref28","doi-asserted-by":"publisher","DOI":"10.1007\/BF00925349"},{"key":"S0031182021000627_ref91","doi-asserted-by":"publisher","DOI":"10.1179\/136485906X118468"},{"key":"S0031182021000627_ref68","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.132217"},{"key":"S0031182021000627_ref46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009337"},{"key":"S0031182021000627_ref142","unstructured":"WHO (2019) WHO | Preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups. WHO."},{"key":"S0031182021000627_ref73","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182007002582"},{"key":"S0031182021000627_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2013.02.009"},{"key":"S0031182021000627_ref65","first-page":"405","article-title":"Immune mechanisms to Ascaris suum in inbred Guinea pigs. I. Passive transfer of immunity by cells or serum","volume":"32","author":"Khoury","year":"1977","journal-title":"Immunology"},{"key":"S0031182021000627_ref32","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009990850"},{"key":"S0031182021000627_ref101","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007896"},{"key":"S0031182021000627_ref25","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.2016016545"},{"key":"S0031182021000627_ref148","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S167292"},{"key":"S0031182021000627_ref30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1997.d01-320.x"},{"key":"S0031182021000627_ref63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001621"},{"key":"S0031182021000627_ref38","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12326"},{"key":"S0031182021000627_ref10","doi-asserted-by":"publisher","DOI":"10.1086\/652784"},{"key":"S0031182021000627_ref85","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2016.08.006"},{"key":"S0031182021000627_ref143","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2008.85"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182021000627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T10:41:05Z","timestamp":1645699265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182021000627\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,12]]},"references-count":148,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S0031182021000627"],"URL":"https:\/\/doi.org\/10.1017\/s0031182021000627","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,12]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2021. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}