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It is a Class II drug poorly water-soluble, with very low bioavailability, a feature particularly limiting to treat the trichinellosis chronic phase. Microcrystals obtained by controlled precipitation using hydroxyethyl cellulose and chitosan have previously been shown to improve ABZ biopharmaceutical properties. This investigation aimed to test the systems' <jats:italic>in vivo<\/jats:italic> efficacy in the CBi-IGE murine model of <jats:italic>Trichinella spiralis<\/jats:italic> infection in the infection's different phases and parasite\u2019 stages. Treatment in the enteral phase led to a 90% decrease in the larval muscle load, probably due to its effect on <jats:italic>T. spiralis<\/jats:italic> female fecundity. Both microcrystal systems given in the migratory phase halved muscle load in males, a response not observed in females. The chitosan-based microcrystals proved to be the best when administered in the chronic phase of the infection \u2013 an increased proportion of L1 dead larvae was found compared to controls, except in CBi+-treated females. Males and females from the highly susceptible CBi+ line presented a significantly different treatment response in this phase. <jats:italic>In vivo<\/jats:italic> efficacy depended on the host genotype and sex and was related to the parasite cycle stage in which the formulations were administered.<\/jats:p>","DOI":"10.1017\/s0031182021001128","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T11:08:36Z","timestamp":1627038516000},"page":"1545-1553","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Effect of sex and genotype of the host on the anthelmintic efficacy of albendazole microcrystals, in the CBi-IGE <i>Trichinella<\/i> infection murine model"],"prefix":"10.1017","volume":"148","author":[{"given":"Ana V.","family":"Codina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7493-3047","authenticated-orcid":false,"given":"Josefina","family":"Priotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dar\u00edo","family":"Leonardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda D.","family":"Vasconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6738-1918","authenticated-orcid":false,"given":"Mar\u00eda C.","family":"Lamas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucila I.","family":"Hinrichsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,7,7]]},"reference":[{"volume-title":"Guide for the Care and Use of Laboratory Animals","year":"2011","key":"S0031182021001128_ref47"},{"key":"S0031182021001128_ref60","doi-asserted-by":"publisher","DOI":"10.2174\/1389200220666191021094906"},{"key":"S0031182021001128_ref57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007657"},{"key":"S0031182021001128_ref31","doi-asserted-by":"publisher","DOI":"10.1177\/104063870301500217"},{"key":"S0031182021001128_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2006.08.003"},{"key":"S0031182021001128_ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.07.040"},{"key":"S0031182021001128_ref46","doi-asserted-by":"publisher","DOI":"10.3201\/eid1712.110896"},{"key":"S0031182021001128_ref27","first-page":"1","article-title":"Use of an original murine model from Argentina in the characterization of complex phenotypes","volume":"21","author":"Hinrichsen","year":"2010","journal-title":"Journal of Basic and Applied Genetics"},{"key":"S0031182021001128_ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2008.01.019"},{"key":"S0031182021001128_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2008.08.006"},{"key":"S0031182021001128_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2016.03.020"},{"volume-title":"Handbook of Parametric and Nonparametric Statistical Procedures","year":"2011","author":"Sheskin","key":"S0031182021001128_ref54"},{"key":"S0031182021001128_ref41","unstructured":"Ministerio de Salud y Desarrollo Social de la Naci\u00f3n, Direcci\u00f3n Nacional de Epidemiolog\u00eda y An\u00e1lisis de la Situaci\u00f3n de Salud (2019) Triquinelosis, Bolet\u00edn integrado de vigilancia 459, SE 30\/2019, 63. 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