{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:55:06Z","timestamp":1747173306321,"version":"3.40.5"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"funder":[{"name":"Institutional Program for Scientific Initiation Scholarships of Evandro Chagas Institute"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This research aims to determine whether the combination of epidemiological and clinical features can predict malaria. Diagnostic investigation detected 22.3% of individuals with <jats:italic>Plasmodium vivax<\/jats:italic> (<jats:italic>P. vivax<\/jats:italic>) malaria, with significant predominance of the male gender. The malaria triad (fever, chills and headache) had a more expressive frequency (81.1%) in individuals with positive thick blood than those with negative thick blood smear (65.1%), although there was no statistical significance. Among the variables analysed as predictive for positive thick blood smear, it was observed that personal history of travel to an endemic malaria area and past malaria infection (PMI) were significantly associated with malaria, even in multiple logistic regression. Fever had the higher sensitivity (94.6%) and past malaria history had the greater specificity (68.2%), with accuracy of 23.5% and 67.5%, respectively. In combined analysis, fever with chills had the highest sensitivity (91.9%), but low accuracy (38.5%). High specificity (91.5%) was found in the association of malaria triad, PMI and history of travel to endemic malaria area (which along with anorexia, was higher 94.6%), with good accuracy (80.7%), suggesting that the screening of patients for performing thick blood smear can be based on these data. The epidemiological features and the malaria triad (fever, chills and headache) can be predictors for identification of malaria patients, concurring to precocious diagnosis and immediate treatment of individuals with malaria.<\/jats:p>","DOI":"10.1017\/s0031182021001165","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T08:51:46Z","timestamp":1625475106000},"page":"10-14","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of malaria clinical\u2212epidemiological predictors in individuals from Brazilian Amazon"],"prefix":"10.1017","volume":"149","author":[{"given":"Paulo Guilherme Souza","family":"Lisb\u00f4a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janaina Maria Rodrigues","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur Vin\u00edcius","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Fernando Barros","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique Ot\u00e1vio Coutinho","family":"Sanches","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane L\u00facia Gomes","family":"da Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wender de Jesus Pena","family":"Correa Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela G\u00f3es","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania do Socorro Souza","family":"Chaves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4737-1533","authenticated-orcid":false,"given":"Ana Maria Revoredo","family":"da Silva Ventura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosana Maria Feio","family":"Libonati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,7,5]]},"reference":[{"volume-title":"BIOESTAT \u2013 Aplica\u00e7\u00f5es estat\u00edsticas nas \u00e1reas das Ci\u00eancias Bio-M\u00e9dicas","year":"2007","key":"S0031182021001165_ref5"},{"volume-title":"World Malaria Report 2019","year":"2019","key":"S0031182021001165_ref26"},{"key":"S0031182021001165_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c930"},{"key":"S0031182021001165_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61655-4"},{"key":"S0031182021001165_ref13","first-page":"1","article-title":"Diagnosis of malaria parasites Plasmodium spp. in endemic areas: current strategies for an ancient disease","volume":"42","author":"Gitta","year":"2019","journal-title":"BioEssays"},{"key":"S0031182021001165_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17446-1"},{"key":"S0031182021001165_ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-017-4398-1"},{"key":"S0031182021001165_ref22","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-274"},{"key":"S0031182021001165_ref20","unstructured":"Raposo, CCBS (2006) Mal\u00e1ria vivax na Pr\u00e9-Amaz\u00f4nia Maranhense: aspectos epidemiol\u00f3gicos e caracter\u00edsticas cl\u00ednicas (Master's thesis). Universidade de Bras\u00edlia, Bras\u00edlia. Retrieved from Reposit\u00f3rio Institucional da Universidade Federal de Bras\u00edlia website. Available at https:\/\/repositorio.unb.br\/handle\/10482\/7546 (Accessed 02 July 2020)."},{"volume-title":"Management of the Child with a Serious Infection or Severe Malnutrition","year":"2000","key":"S0031182021001165_ref24"},{"volume-title":"Guidelines for the Treatment of Malaria","year":"2015","key":"S0031182021001165_ref25"},{"key":"S0031182021001165_ref23","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2009.47.2.93"},{"key":"S0031182021001165_ref4","first-page":"78","volume-title":"Diagnostico de Malaria","author":"Antu\u00f1ano","year":"1988"},{"key":"S0031182021001165_ref15","unstructured":"IBGE (2010) Instituto Brasileiro de Geografia e Estat\u00edstica. Sinopse do Censo Demogr\u00e1fico 2010. 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