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Soluble somatic fractions (SSF) and membrane somatic fractions (MSF) and excretory\u2212secretory (E\/S) products from <jats:italic>S. venezuelensis<\/jats:italic> infective larvae were evaluated against 71 sera from individuals with strongyloidiasis, 105 sera from healthy individuals, and 84 sera from individuals with other helminth infections. Using an ELISA cut-off for 100% sensitivity, E\/S products were 97.88% specific followed by MSF (93.12%) and then by SSF (85.2%). The occurrence of cross-reactivity with other helminths was 4.76% (4\/84) with E\/S products, 8.33% (7\/84) with MSF, and 17.86% (15\/84) with SSF. For a cut-off for 100% specificity, E\/S products showed a sensitivity of 88.73% whereas MSF and SSF showed sensitivities of 59.15% and 53.52%, respectively. In conclusion, E\/S products were the best antigenic option for the serodiagnosis of human strongyloidiasis.<\/jats:p>","DOI":"10.1017\/s0031182021001207","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T03:06:16Z","timestamp":1625454376000},"page":"1522-1527","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Diagnostic accuracy of somatic and excretory\u2212secretory antigens from <i>Strongyloides venezuelensis<\/i> infective larvae for the immunodiagnosis of human strongyloidiasis"],"prefix":"10.1017","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4450-5372","authenticated-orcid":false,"given":"William Henry","family":"Rold\u00e1n Gonz\u00e1les","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirce Mary Correia 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