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A prospective, descriptive, observational study was conducted to evaluate clinical and parasitological evolution after ivermectin treatment of 41 patients infected with\n                    <jats:italic>S. stercoralis<\/jats:italic>\n                    . Reactivation of the disease was defined both by clinical symptoms appearance and\/or direct larvae detection 30 days after treatment or later. We described 10 haplotypes organized in two clusters. Most frequent variants were also described in the Asian continent in human (HP24 and HP93) and canine (HP24) samples. Clinical presentation (intestinal, severe, cutaneous and asymptomatic), immunological status and eosinophil count were not associated with specific haplotypes or clusters. Nevertheless, presence of cluster 1 haplotypes during diagnosis increased the risk of reactivation with an odds ratio (OR) of 7.51 [confidence interval (CI) 95% 1.38\u201344.29,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.026]. In contrast, reactivation probability was 83 times lower if cluster 2 (I152V mutation) was detected (OR = 0.17, CI 95% 0.02\u20130.80,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.02). This is the first analysis of\n                    <jats:italic>S. stercoralis cox<\/jats:italic>\n                    1 diversity in the clinical context. Determination of clusters during the diagnosis could facilitate and improve the design of follow-up strategies to prevent severe reactivations of this chronic disease.\n                  <\/jats:p>","DOI":"10.1017\/s0031182021001517","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T15:04:37Z","timestamp":1630940677000},"page":"24-34","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Molecular typing of\n                    <i>Strongyloides stercoralis<\/i>\n                    in Latin America, the clinical connection"],"prefix":"10.1017","volume":"149","author":[{"given":"Silvia Anal\u00eda","family":"Repetto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0870-6131","authenticated-orcid":false,"given":"Juan","family":"Quarroz 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