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As part of the ongoing evaluation of the rhesus macaque model of severe malaria, a detailed ultrastructural analysis of the interaction between the parasite and both the host erythrocytes and the microvasculature was undertaken. Tissue (brain, heart and kidney) from splenectomized rhesus macaques and blood from spleen-intact animals infected with <jats:italic>P. coatneyi<\/jats:italic> were examined by electron microscopy. In all three tissues, similar interactions (sequestration) between infected red blood cells (iRBC) and blood vessels were observed with evidence of rosette and auto-agglutinate formation. The iRBCs possessed caveolae similar to <jats:italic>P. vivax<\/jats:italic> and knob-like structures similar to <jats:italic>P. falciparum<\/jats:italic>. However, the knobs often appeared incompletely formed in the splenectomized animals in contrast to the intact knobs exhibited by spleen intact animals. <jats:italic>Plasmodium coatneyi<\/jats:italic> infection in the monkey replicates many of the ultrastructural features particularly associated with <jats:italic>P. falciparum<\/jats:italic> in humans and as such supports its use as a suitable animal model. However, the possible effect on host\u2013parasite interactions and the pathogenesis of disease due to the use of splenectomized animals needs to be taken into consideration.<\/jats:p>","DOI":"10.1017\/s0031182021001669","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T08:44:46Z","timestamp":1633337086000},"page":"161-170","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Ultrastructural characterization of host\u2013parasite interactions of <i>Plasmodium coatneyi<\/i> in rhesus macaques"],"prefix":"10.1017","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9576-9186","authenticated-orcid":false,"given":"E. 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