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However, studies have suggested that in some specific helminths, eosinophils may promote the needs and longevity of these parasites, and their role in these infections remains undefined, including in <jats:italic>Toxocara canis<\/jats:italic> infection. Thus, this study aimed to investigate the role of eosinophils in the context of larval migration of <jats:italic>T. canis<\/jats:italic> and the immunopathological aspects of infection. For this, we used wild-type mice and mice genetically deficient for the transcription factor GATA-binding factor 1 (GATA1<jats:sup>\u2212\/\u2212<\/jats:sup>), infected with 1000 eggs of <jats:italic>T. canis<\/jats:italic>. At 0, 3, 14 and 63 days post-infection, parasite load, tissue cytokine production, leucocyte profile, bronchoalveolar lavage cells and histopathological analyses were carried out. Collectively, our results demonstrate that the presence of eosinophils mediates susceptibility to <jats:italic>T. canis<\/jats:italic>, inducing leucocytosis and the formation of granulomas, increasing the pulmonary and cerebral parasite load, and reducing the number of neutrophils, which may be necessary to control the infection.<\/jats:p>","DOI":"10.1017\/s0031182022000075","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T05:33:13Z","timestamp":1644471193000},"page":"893-904","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":9,"title":["Tissue eosinophilia correlates with mice susceptibility, granuloma formation and damage during <i>Toxocara canis<\/i> infection"],"prefix":"10.1017","volume":"149","author":[{"given":"Tha\u00eds","family":"Leal-Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"de Almeida 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