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In <jats:italic>E. caproni<\/jats:italic> infections in mice, interleukin-25 (IL-25) plays a critical role and it is required for the resistance to infection. However, little is known on the factors that determine its production. Primary <jats:italic>E. caproni<\/jats:italic> infection in mice is characterized by the development of chronic infections and elevated worm recovery, in relation to a local Th1 response with elevated production of interferon-<jats:italic>\u03b3<\/jats:italic>. However, partial resistance against secondary <jats:italic>E. caproni<\/jats:italic> infections in ICR (Institute of Cancer Research) mice is developed after the chemotherapeutic cure of a primary infection and the innately produced IL-25 after pharmacological treatment. In this paper, we analyse the potential role of intestinal microbiota in the production of IL-25, and the subsequent resistance to infection. For this purpose, we analysed the production of IL-25 under conditions of experimental dysbiosis and also the changes in the resident microbiota in primary infections, pharmacological curation and secondary infections. The results obtained showed that resident microbiota play a major role in the production of IL-25 and the appearance of members of the phylum Verrucomicrobia as a consequence of the curation of the primary infection could be related to the partial resistance to secondary infection.<\/jats:p>","DOI":"10.1017\/s0031182022001366","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T05:59:30Z","timestamp":1664517570000},"page":"1781-1793","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Changes in resident microbiota associated with mice susceptibility or resistance to the intestinal trematode <i>Echinostoma caproni<\/i>"],"prefix":"10.1017","volume":"149","author":[{"given":"Maria","family":"\u00c1lvarez-Izquierdo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Fiallos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Cociancic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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