{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:41:40Z","timestamp":1780411300243,"version":"3.54.1"},"reference-count":49,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 109-2320-B-303-007"],"award-info":[{"award-number":["MOST 109-2320-B-303-007"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Angiostrongylus cantonensis<\/jats:italic>causes a form of parasitic meningitis in humans. Albendazole (ABZ) kills nematode larvae in the brain. However, dead larvae can trigger a severe inflammatory response, resulting in brain damage. Accumulating evidence suggests that calycosin represents a potential anti-inflammatory therapeutic candidate. In this study, we investigated the combined effects of ABZ and calycosin in angiostrongyliasis caused by<jats:italic>A. cantonensis<\/jats:italic>in BALB\/c mice. Inflammatory mediators (such as phospho-nuclear factor-<jats:italic>\u03ba<\/jats:italic>B, cyclooxygenase-2, matrix metalloproteinase-9, tumour necrosis factor-<jats:italic>\u03b1<\/jats:italic>and interleukin-1<jats:italic>\u03b2<\/jats:italic>) are associated with the development of meningitis and immune inflammatory reactions. We found that<jats:italic>A. cantonensis<\/jats:italic>significantly induces inflammatory mediator production and increases the blood\u2013brain barrier (BBB) permeability. However, co-administration of both ABZ and calycosin markedly suppressed meningitis and inflammatory mediator production and decreased the BBB permeability compared to treatment with a single drug. Furthermore, calycosin and ABZ plus calycosin treatment facilitated production of the antioxidant haem oxygenase-1 (HO-1). Moreover, co-therapy with ABZ and calycosin failed to mitigate angiostrongyliasis in the presence of tin-protoporphyrin IX, an HO-1-specific inhibitor. This finding suggests that the beneficial effects of ABZ plus calycosin treatment on the regulation of inflammation are mediated by the modulation of HO-1 activation. The present results provide new insights into the treatment of human angiostrongyliasis using co-therapy with ABZ and calycosin.<\/jats:p>","DOI":"10.1017\/s0031182022001408","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T09:42:29Z","timestamp":1667814149000},"page":"311-320","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Calycosin attenuates<i>Angiostrongylus cantonensis<\/i>-induced parasitic meningitis through modulation of HO-1 and NF-<i>\u03ba<\/i>B activation"],"prefix":"10.1017","volume":"150","author":[{"given":"Cheng-You","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Wen","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Chan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Jung","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Tang","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Yang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2251-6900","authenticated-orcid":false,"given":"Tso-Fu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"S0031182022001408_ref25","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1079\/JOH2004256","article-title":"Induced 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\u00a9 The Author(s), 2022. 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