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To gain a better insight into the epidemiology of<jats:italic>Giardia<\/jats:italic>in Africa, we undertook a robust study to comprehend the distribution and prevalence of<jats:italic>Giardia<\/jats:italic>infection in humans, animals and their dispersal in the environment. Our protocol was registered with PROSPERO (registration number CRD42022317653). Deep literature search from 5 electronic databases, namely, AJOL, Google scholar, PubMed, ScienceDirect and Springer Link was performed using relevant keywords. Meta-analysis was performed using a random-effects model and heterogeneity among studies was evaluated using Cochran's Q and the<jats:italic>I<jats:sup>2<\/jats:sup><\/jats:italic>-statistic. More than 500 eligible studies published from 1 January 1980 until 22 March 2022 were retrieved. In humans, exactly 48 124<jats:italic>Giardia<\/jats:italic>spp. infection cases were registered from the 494 014 stool samples examined resulting in a pooled prevalence estimate (PPE) of 8.8% using microscopy. Whereas copro-antigen tests and molecular diagnostic methods generated PPE of 14.3 and 19.5%, respectively, with HIV+ subjects and those with diarrhoeatic stool having infection rates of 5.0 and 12.3%, respectively. The PPE of<jats:italic>Giardia<\/jats:italic>spp. infection in animals using molecular methods was 15.6%, which was most prevalent in pigs (25.2%) with Nigeria registering the highest prevalence at 20.1%. The PPE of<jats:italic>Giardia<\/jats:italic>spp. contamination from waterbodies was 11.9% from a total of 7950 samples which were detected using microscopy, with Tunisia documenting the highest infection rate of 37.3%. This meta-analysis highlights the necessity of \u2018One Health\u2019 approach for consolidated epidemiological studies and control of giardiasis in the African continent.<\/jats:p>","DOI":"10.1017\/s0031182023000513","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:09:33Z","timestamp":1685351373000},"page":"769-780","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":38,"title":["A \u2018One Health\u2019 perspective of Africa-wide distribution and prevalence of Giardia species in humans, animals and waterbodies: a systematic review and meta-analysis"],"prefix":"10.1017","volume":"150","author":[{"given":"Mpho","family":"Tawana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ThankGod 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