{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:47:15Z","timestamp":1782845235924,"version":"3.54.5"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hookworm infection affects millions globally, leading to chronic conditions like malnutrition and anaemia. Among the hookworm species, <jats:italic>Ancylostoma ceylanicum<\/jats:italic> stands out as a generalist, capable of infecting various hosts, including humans, cats, dogs and hamsters. Surprisingly, it cannot establish in mice, despite their close phylogenetic relationship to hamsters. The present study investigated the development of <jats:italic>A. ceylanicum<\/jats:italic> in immunodeficient NSG mice to determine the contribution of the immune system to host restriction. The infections became patent on day 19 post-infection (PI) and exhibited elevated egg production which lasted for at least 160 days PI. Infective <jats:italic>A. ceylanicum<\/jats:italic> larvae reared from eggs released by infected NSG mice were infectious to hamsters and capable of reproduction, indicating that the adults in the NSG mice were producing viable offspring. In contrast, <jats:italic>A. ceylanicum<\/jats:italic> showed limited development in outbred Swiss Webster mice. Furthermore, the closely related canine hookworm <jats:italic>Ancylostoma caninum<\/jats:italic> was unable to infect and develop in NSG mice, indicating that different mechanisms may determine host specificity even in closely related species. This is the first report of any hookworm species completing its life cycle in a mouse and implicate the immune system in determining host specificity in <jats:italic>A. ceylanicum<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0031182023001208","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T09:18:16Z","timestamp":1701249496000},"page":"102-107","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Immunity mediates host specificity in the human hookworm <i>Ancylostoma ceylanicum<\/i>"],"prefix":"10.1017","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5132-6420","authenticated-orcid":false,"given":"Andrea","family":"Langeland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise L.","family":"McKean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5752-2131","authenticated-orcid":false,"given":"Damien M.","family":"O'Halloran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-1413","authenticated-orcid":false,"given":"John M.","family":"Hawdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"S0031182023001208_ref19","volume-title":"Guide for the Care and Use of Laboratory Animals","year":"2011"},{"key":"S0031182023001208_ref32","volume-title":"Animal Welfare Act, US","year":"2018"},{"key":"S0031182023001208_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59874-8"},{"key":"S0031182023001208_ref18","article-title":"Altered larval activation response associated with multidrug resistance in the canine hookworm Ancylostoma caninum","author":"McKean","year":"2023","journal-title":"Parasitology"},{"key":"S0031182023001208_ref22","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-7-37"},{"key":"S0031182023001208_ref6","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1972.21.300"},{"key":"S0031182023001208_ref20","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X19000130"},{"key":"S0031182023001208_ref24","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1999.00410.x"},{"key":"S0031182023001208_ref23","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000046643"},{"key":"S0031182023001208_ref25","unstructured":"Schad, GA (1990) Hypobiosis and related phenomena in hookworm infection. In Schad GA and Warren KS (eds), Hookworm Disease \u2013 Current Status and New Directions. Taylor & Francis Ltd, pp. 71\u201388."},{"key":"S0031182023001208_ref10","first-page":"50","article-title":"A new technique for counting nematode eggs in sheep faeces","volume":"12","author":"Gordon","year":"1939","journal-title":"Journal of the Council for Scientific and Industrial Research"},{"key":"S0031182023001208_ref12","first-page":"140","article-title":"Long-term storage of hookworm infective larvae in buffered saline solution maintains larval responsiveness to host signals","volume":"58","author":"Hawdon","year":"1991","journal-title":"Journal of the Helminthological Society of Washington"},{"key":"S0031182023001208_ref29","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/65.1.153"},{"key":"S0031182023001208_ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004891"},{"key":"S0031182023001208_ref17","doi-asserted-by":"publisher","DOI":"10.2307\/3279448"},{"key":"S0031182023001208_ref7","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.39"},{"key":"S0031182023001208_ref2","volume-title":"Georgis\u2019 Parasitology for Veterinarians","author":"Bowman","year":"2014"},{"key":"S0031182023001208_ref28","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.6477"},{"key":"S0031182023001208_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-382008-2.00001-5"},{"key":"S0031182023001208_ref5","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.4.1880-1886.2003"},{"key":"S0031182023001208_ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000291"},{"key":"S0031182023001208_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2018.12.004"},{"key":"S0031182023001208_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-53230-7_9"},{"key":"S0031182023001208_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.12.001"},{"key":"S0031182023001208_ref1","first-page":"41","volume-title":"A Simple Method for the Detection of Ankylostomum (Nematode) Larvae in Soil Tests","author":"Baermann","year":"1917"},{"key":"S0031182023001208_ref30","first-page":"1693","article-title":"Infectivity of Ancylostoma caninum larvae from canine milk","volume":"31","author":"Stone","year":"1970","journal-title":"American Journal of Veterinary Research"},{"key":"S0031182023001208_ref16","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182023000227"},{"key":"S0031182023001208_ref21","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-44301-4"},{"key":"S0031182023001208_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(82)90039-X"},{"key":"S0031182023001208_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(99)90007-X"},{"key":"S0031182023001208_ref31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0450.1976.tb00659.x"},{"key":"S0031182023001208_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90277-3"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182023001208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T07:37:57Z","timestamp":1707809877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182023001208\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,29]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S0031182023001208"],"URL":"https:\/\/doi.org\/10.1017\/s0031182023001208","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,29]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2023. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}