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The paper includes histopathological investigation with identification of innate immune cells involved in host reaction and molecular data allowed correct designation of the cestode species. Of 35 specimens of chub examined, 21 (60%) harboured individuals of <jats:italic>C. brachycollis<\/jats:italic> and a total of 1619 tapeworms were counted, the intensity of infection ranged from 1 to 390 worms per fish (46.2 \u00b1 15.3, mean \u00b1 <jats:sc>s.e.<\/jats:sc>). Histopathological and ultrastructural investigations showed strict contact between the worm's body and the epithelia and increase in the number of mucous cells, rodlet cells among the epithelial cells. Within the tunica propria-submucosa, beneath the site of scolex attachment, numerous neutrophils and mast cells were noticed. This is the first study of the occurrence of <jats:italic>C. brachycollis<\/jats:italic> in chub from Lake Blidinje and on the response of the innate immune cells of <jats:italic>S. tenellus<\/jats:italic> to this tapeworm. Interestingly, in 3 very heavily infected chubs, perforation of the intestinal wall was documented; this is uncommon among cestodes which use fish as a definitive host.<\/jats:p>","DOI":"10.1017\/s0031182023001233","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T09:00:06Z","timestamp":1701421206000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Infection of endemic chub <i>Squalius tenellus<\/i> with the intestinal tapeworm <i>Caryophyllaeus brachycollis<\/i> (Cestoda): histopathology and ultrastructural surveys"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9778-5937","authenticated-orcid":false,"given":"Bahram","family":"Sayyaf 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