{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T03:47:27Z","timestamp":1794023247424,"version":"4.8.0"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"unspecified","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Dipylidium caninum<\/jats:italic>\n                    is a common tapeworm of dogs. Two cases of praziquantel resistance have been described in\n                    <jats:italic>D. caninum<\/jats:italic>\n                    in the United States. No further reports have been published to the authors\u2019 knowledge. Here, the case of a dog imported to Switzerland from Spain with a history of chronic excretion of tapeworm proglottids and unresponsiveness to praziquantel treatments is reported. Clinical signs were mild (restlessness, tenesmus, anal pruritus, squashy feces) and flea infestation could be ruled out. Infection with\n                    <jats:italic>D. caninum<\/jats:italic>\n                    was confirmed through morphological and genetic parasite identification. Different subsequently applied anthelmintic compounds and protocols, including epsiprantel, did not confer the desired effects. Proglottid shedding only stopped after oral mebendazole administration of 86.2 mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    body weight for 5 consecutive days. Clinical signs resolved and the dog remained coproscopically negative during a follow-up period of 10 months after the last treatment. This case represents the first reported apparent praziquantel and epsiprantel resistance in\n                    <jats:italic>D. caninum<\/jats:italic>\n                    in Europe. Treatment was extremely challenging especially due to the limited availability of efficacious alternative compounds.\n                  <\/jats:p>","DOI":"10.1017\/s0031182024000398","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T01:25:46Z","timestamp":1712193946000},"page":"523-528","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":13,"title":["First report of apparent praziquantel resistance in\n                    <i>Dipylidium caninum<\/i>\n                    in Europe"],"prefix":"10.1017","volume":"151","author":[{"given":"Andreas W.","family":"Oehm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Reiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Binz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6523-7952","authenticated-orcid":false,"given":"Manuela","family":"Schnyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"S0031182024000398_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2018.05.001"},{"key":"S0031182024000398_ref24","doi-asserted-by":"publisher","DOI":"10.1136\/vr.c4661"},{"key":"S0031182024000398_ref2","first-page":"1799","article-title":"Critical studies of fenbendazole suspension (10%) against naturally occurring helminth infections in dogs","volume":"39","author":"Burke","year":"1978","journal-title":"American Journal of Veterinary Research"},{"key":"S0031182024000398_ref11","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.18-0533"},{"key":"S0031182024000398_ref14","first-page":"36","article-title":"Reflecting on the past and fast forwarding to present day anthelmintic resistant Ancylostoma caninum \u2013 a critical issue we neglected to forecast","volume":"22","author":"Marsh","year":"2023","journal-title":"International Journal for Parasitology: Drugs and Drug Resistance"},{"key":"S0031182024000398_ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s12639-013-0281-x"},{"key":"S0031182024000398_ref30","unstructured":"VICH (International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products) (2000) Efficacy of anthelmintics: general requirements. Guideline 7. Available at https:\/\/www.vichsec.org\/en\/guidelines.html (accessed 5 March 2024)."},{"key":"S0031182024000398_ref9","first-page":"77","article-title":"Field trials of the anthelmintic efficacy of nitroscanate and mebendazole in dogs","volume":"126","author":"Genchi","year":"1990","journal-title":"Veterinary Record"},{"key":"S0031182024000398_ref21","doi-asserted-by":"publisher","DOI":"10.3390\/ani8070108"},{"key":"S0031182024000398_ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-022-05559-2"},{"key":"S0031182024000398_ref32","first-page":"36","article-title":"Spread of anthelmintic resistance in intestinal helminths of dogs and cats is currently less pronounced than in ruminants and horses \u2013 yet it is of major concern","volume":"17","author":"Von Samson-Himmelstjerna","year":"2021","journal-title":"International Journal for Parasitology: Drugs and Drug Resistance"},{"key":"S0031182024000398_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-006-0258-0"},{"key":"S0031182024000398_ref17","doi-asserted-by":"publisher","DOI":"10.5858\/2003-127-e157-IBDCIA"},{"key":"S0031182024000398_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2009.07.041"},{"key":"S0031182024000398_ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s12639-015-0706-9"},{"key":"S0031182024000398_ref5","volume-title":"Parasitologie f\u00fcr die Tiermedizin","author":"Deplazes","year":"2021"},{"key":"S0031182024000398_ref18","first-page":"1013","article-title":"Acute hepatic necrosis associated with the administration of mebendazole to dogs","volume":"179","author":"Polzin","year":"1981","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"S0031182024000398_ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-009-1493-y"},{"key":"S0031182024000398_ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1980.tb15983.x"},{"key":"S0031182024000398_ref31","unstructured":"VICH (International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products) (2001) Efficacy of anthelmintics: specific recommendations for canines. Guideline 19. Available at https:\/\/www.vichsec.org\/en\/guidelines.html (accessed 5 March 2024)."},{"key":"S0031182024000398_ref3","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1097\/00006454-199010000-00014","article-title":"Dipylidium caninum, an underrecognized infection in infants and children","volume":"9","author":"Chappell","year":"1990","journal-title":"Pediatric Infectious Diseases Journal"},{"key":"S0031182024000398_ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0258037"},{"key":"S0031182024000398_ref26","first-page":"72","article-title":"Hepatic failure following mebendazole administration to a dog","volume":"181","author":"Swanson","year":"1982","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"S0031182024000398_ref12","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1992.53.12.2272"},{"key":"S0031182024000398_ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-009-1489-7"},{"key":"S0031182024000398_ref19","first-page":"e158","article-title":"Dipylidium caninum infection in children: clinical presentation and therapeutic challenges","volume":"38","author":"Portokalidou","year":"2018","journal-title":"Pediatric Infectious Disease Journal"},{"key":"S0031182024000398_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2006.11.013"},{"key":"S0031182024000398_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2004.04.014"},{"key":"S0031182024000398_ref27","doi-asserted-by":"publisher","DOI":"10.29074\/ascls.24.4.212"},{"key":"S0031182024000398_ref4","first-page":"1076","article-title":"Dose titration and confirmation tests for determination of cesticidal efficacy of epsiprantel in dogs","volume":"50","author":"Corwin","year":"1989","journal-title":"American Journal of Veterinary Research"},{"key":"S0031182024000398_ref7","unstructured":"ESCCAP (European Scientific Counsel Companion. Animal Parasites) (2021) Worm control in dogs and cats. ESCCAP guideline 01. 6th ed. May 2021. Available at https:\/\/www.esccap.org\/uploads\/docs\/oc1bt50t_0778_ESCCAP_GL1_v15_1p.pdf (accessed 12 January 2024)."},{"key":"S0031182024000398_ref28","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182007002235"},{"key":"S0031182024000398_ref29","first-page":"320","article-title":"Anthelmintic effect of mebendazole against nematodes and cestodes in dogs","volume":"80","author":"Vanparijs","year":"1973","journal-title":"Deutsche Tier\u00e4rztliche Wochenschrift"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182024000398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T06:08:41Z","timestamp":1715926121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182024000398\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S0031182024000398"],"URL":"https:\/\/doi.org\/10.1017\/s0031182024000398","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2024. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is used to distribute the re-used or adapted article and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}