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In addition to public health concerns, <jats:italic>S<\/jats:italic>. <jats:italic>stercoralis<\/jats:italic> also infects dogs, which represent a possible reservoir for potentially zoonotic transmissions. We describe the first confirmed case of fatal disseminated infection in a dog in the Czech Republic. The microscopic and histological results were supported by a complex genotyping approach. Using high-throughput sequencing of the hypervariable region (HVR-IV) of 18S rDNA and Sanger sequencing of the partial cytochrome c oxidase subunit 1 gene (<jats:italic>cox1<\/jats:italic>), the potentially zoonotic haplotype\/lineage A of <jats:italic>S<\/jats:italic>. <jats:italic>stercoralis<\/jats:italic> was confirmed, while the solely canine haplotype\/lineage B was not found. The development of the disease is mainly associated with immunodeficiency, and in this case, it was triggered by inappropriate treatment, in particular the use of corticosteroids.<\/jats:p>","DOI":"10.1017\/s0031182024000568","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T01:12:09Z","timestamp":1715130729000},"page":"587-593","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["High-throughput sequencing of <i>Strongyloides stercoralis<\/i> \u2013 a fatal disseminated infection in a 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