{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T15:36:51Z","timestamp":1767713811625,"version":"3.38.0"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"unspecified","delay-in-days":50,"URL":"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100016123","name":"European Union","doi-asserted-by":"publisher","award":["Part of the EDCTP2 programme"],"award-info":[{"award-number":["Part of the EDCTP2 programme"]}],"id":[{"id":"10.13039\/100016123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Schistosomiasis is a neglected tropical disease with significant health implications, particularly among children. A cross-sectional study was conducted among school-aged children (SAC) in Mwanga district, Tanzania, a region known to be co-endemic for <jats:italic>S. haematobium<\/jats:italic> and <jats:italic>S. mansoni<\/jats:italic> infection and where annual mass drug administration (MDA) has been conducted for 20 years. In total, 576 SAC from 5 schools provided a urine sample for the detection of <jats:italic>Schistosoma<\/jats:italic> circulating anodic antigen using the upconverting particle-based lateral flow (UCP-LF CAA) test. Additionally, the potential of the point-of-care circulating cathodic antigen (POC-CCA) and microhaematuria dipstick test as field-applicable diagnostic alternatives for schistosomiasis were assessed and the prevalence outcome compared to UCP-LF CAA. Risk factors associated with schistosomiasis was assessed based on UCP-LF CAA. The UCP-LF CAA test revealed an overall schistosomiasis prevalence of 20.3%, compared to 65.3% based on a combination of POC-CCA and microhaematuria dipstick. No agreement was observed between the combined POC tests and UCP-LF CAA. Factors associated with schistosomiasis included age (5\u201310 years), involvement in fishing, farming, swimming activities and attending 2 of the 5 primary schools. Our findings suggest a significant progress in infection control in Mwanga district due to annual MDA, although not enough to interrupt transmission. Accurate diagnostics play a crucial role in monitoring intervention measures to effectively combat schistosomiasis.<\/jats:p>","DOI":"10.1017\/s0031182024001045","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T07:00:08Z","timestamp":1729494008000},"page":"1254-1259","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Current status of schistosomiasis in school-aged children in Mwanga district, Tanzania: impact of two decades of annual Mass Drug Administration programme"],"prefix":"10.1017","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6304-5343","authenticated-orcid":false,"given":"Jeremia J.","family":"Pyuza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2068-1563","authenticated-orcid":false,"given":"Brice","family":"Meulah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pytsje T.","family":"Hoekstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel","family":"Mdende","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Mvilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisette van","family":"Lieshout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stan T.","family":"Hilt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul L. 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Available at https:\/\/www.finddx.org\/what-we-do\/projects\/rapid-test-for-precision-mapping-and-monitoring-and-evaluation-of-schistosomiasis-control-programmes\/ (accessed 12 June 2024)."},{"key":"S0031182024001045_ref22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228770"},{"key":"S0031182024001045_ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005937"},{"key":"S0031182024001045_ref2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.21-0031"},{"key":"S0031182024001045_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01594.x"},{"key":"S0031182024001045_ref25","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.19-0843"},{"key":"S0031182024001045_ref26","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009579.pub2"},{"key":"S0031182024001045_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(98)01318-0"},{"key":"S0031182024001045_ref34","unstructured":"World Health Organization (WHO) (2023) Schistosomiasis facts 2023. 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