{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:29:02Z","timestamp":1789576142727,"version":"build-2803163510"},"reference-count":58,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Dioctophyme renale<\/jats:italic>\n                    , the giant kidney worm, is a nematode related to\n                    <jats:italic>Trichuris<\/jats:italic>\n                    sp and is distributed worldwide. These parasites locate in the kidney of their definitive hosts (mainly belonging to the order Carnivora) and have an indirect life cycle with an annelid as the main intermediate host. Humans are rarely affected, but in those that are, 1 or both kidneys are destroyed. In South America,\n                    <jats:italic>D. renale<\/jats:italic>\n                    is widespread in riparian regions where changing climatic conditions, environmental degradation, and compromised sanitation are increasing the risk of distribution of this parasite, including humans. Here, we provide the descriptions of the genetic diversity of the parasite in the region by analysing 73 adult\n                    <jats:italic>D. renale<\/jats:italic>\n                    samples collected from domestic and wild carnivores. The most common hosts were (\n                    <jats:italic>Canis lupus familiaris)<\/jats:italic>\n                    and maned wolf (\n                    <jats:italic>Chrysocyon brachyurus<\/jats:italic>\n                    Fam. Canidae) among domestic and wild carnivores, respectively. This work shows the descriptions of the genetic diversity of this parasite complementing molecular methods and classical and probabilistic phylogeography. Our results strongly suggest that this parasite has been present on the continent long enough to develop local genetic variants. Also, the phylogenies show transmission between localities and bidirectional transmission between domestic and wild species. We now have new tools to understand the ecological dynamics of this parasite such as molecular markers to study its genetic diversity as well as for identification and reporting in cryptic cases.\n                  <\/jats:p>","DOI":"10.1017\/s0031182024001379","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:14:31Z","timestamp":1730074471000},"page":"776-786","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Genetic diversity of\n                    <i>Dioctophyme renale<\/i>\n                    in Southern South America"],"prefix":"10.1017","volume":"152","author":[{"given":"Lucas F.","family":"Arce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Facelli Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahili","family":"Giorello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Butti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas L.","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"Arrabal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda B.","family":"Natalini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6737-3771","authenticated-orcid":false,"given":"Mart\u00edn","family":"Kowalewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pedrassani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Silveira Mascarenhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josaine C.","family":"da Silva Rappeti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Zilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5039-8975","authenticated-orcid":false,"given":"Pablo M.","family":"Beldomenico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Lia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela R.","family":"Franchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3778-4833","authenticated-orcid":false,"given":"Laura","family":"Kamenetzky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"S0031182024001379_ref46","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a004034"},{"key":"S0031182024001379_ref22","first-page":"1","article-title":"Gene genealogies and the coalescent process","volume":"7","author":"Hudson","year":"1990","journal-title":"Oxford Surveys in Evolutionary Biology"},{"key":"S0031182024001379_ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006650"},{"key":"S0031182024001379_ref44","first-page":"43","article-title":"Occurrence of dioctophymosis in canines within a riparian zone of the R\u00edo de La Plata watercourse, in Ensenada, Buenos Aires Province, Argentina","volume":"10","author":"Radman","year":"2017","journal-title":"Veterinary Parasitology: Regional Studies and Reports"},{"key":"S0031182024001379_ref2","first-page":"3","volume-title":"Esquema biogeogr\u00e1fico de la Rep\u00fablica Argentina","volume":"56","author":"Arana"},{"key":"S0031182024001379_ref49","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/123.3.597"},{"key":"S0031182024001379_ref25","doi-asserted-by":"publisher","DOI":"10.1654\/4366.1"},{"key":"S0031182024001379_ref53","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.22.4673"},{"key":"S0031182024001379_ref28","doi-asserted-by":"publisher","DOI":"10.1645\/GE-2132.1"},{"key":"S0031182024001379_ref13","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/131.2.479"},{"key":"S0031182024001379_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.2007.00189.x"},{"key":"S0031182024001379_ref45","unstructured":"Rambaut, A and Drummond, AJ (2003) Tracer, version 1.2. 1. Program distributed by the author. Available at http:\/\/beast.bio.ed.ac.uk\/Tracer (Accessed 30 July 2024)."},{"key":"S0031182024001379_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2012.04.003"},{"key":"S0031182024001379_ref5","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182014000791"},{"key":"S0031182024001379_ref9","first-page":"100339","article-title":"Dioctophyme renale in a domestic cat (Felis catus): Renal location and nephrectomy","volume":"18","author":"Butti","year":"2019","journal-title":"Veterinary Parasitology: Regional Studies and Reports"},{"key":"S0031182024001379_ref100","unstructured":"Pereyra, FX (2003) Ecoregiones de la Argentina. Anales 37. 208 p. y 1 mapa. Buenos Aires, Argentina: Servicio Geol\u00f3gico Minero Argentino."},{"key":"S0031182024001379_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2017.07.012"},{"key":"S0031182024001379_ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2013.09.015"},{"key":"S0031182024001379_ref42","first-page":"139","article-title":"Nematodes from mammals in Brazil: an updating","volume":"5","author":"Pinto","year":"2011","journal-title":"Neotropical Helminthology"},{"key":"S0031182024001379_ref39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43812-4"},{"key":"S0031182024001379_ref36","doi-asserted-by":"publisher","DOI":"10.7312\/nei-92038"},{"key":"S0031182024001379_ref19","first-page":"95","article-title":"Bioedit: a user friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT","volume":"41","author":"Hall","year":"1999","journal-title":"Nucleid Acids Symposium Series"},{"key":"S0031182024001379_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2020.102269"},{"key":"S0031182024001379_ref31","doi-asserted-by":"publisher","DOI":"10.3391\/bir.2015.4.2.02"},{"key":"S0031182024001379_ref52","doi-asserted-by":"publisher","DOI":"10.1016\/0040-5809(84)90027-3"},{"key":"S0031182024001379_ref24","first-page":"978","volume-title":"Textbook of Parasitic Zoonoses","author":"Khullar","year":"2022"},{"key":"S0031182024001379_ref41","doi-asserted-by":"publisher","DOI":"10.1590\/S1984-29612014018"},{"key":"S0031182024001379_ref40","first-page":"3043","article-title":"A case report of human infection with Dioctophyma renale from Iran","volume":"14","author":"Norouzi","year":"2017","journal-title":"Urology Journal"},{"key":"S0031182024001379_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0888-7543(05)80277-0"},{"key":"S0031182024001379_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a025898"},{"key":"S0031182024001379_ref56","doi-asserted-by":"publisher","DOI":"10.1016\/0040-5809(75)90020-9"},{"key":"S0031182024001379_ref23","doi-asserted-by":"publisher","DOI":"10.4257\/oeco.2017.2101.01"},{"key":"S0031182024001379_ref55","first-page":"223","article-title":"Dioctophyme renale (Nematoda: Dioctophymatidae) in Leopardus geoffroyi (Carnivora: Felidae) in the Neotropical region","volume":"27","author":"Trindade","year":"2018","journal-title":"Brazilian Journal of Veterinary Parasitology"},{"key":"S0031182024001379_ref18","doi-asserted-by":"publisher","DOI":"10.1139\/gen-2020-0140"},{"key":"S0031182024001379_ref47","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msx248"},{"key":"S0031182024001379_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a026036"},{"key":"S0031182024001379_ref14","first-page":"47","article-title":"Arlequin ver. 3.0: an integrated software package for population genetics data analysis","volume":"1","author":"Excoffier","year":"2005","journal-title":"Evolutionary Bioinformatics Online"},{"key":"S0031182024001379_ref20","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2003.0025"},{"key":"S0031182024001379_ref30","first-page":"209","article-title":"The detection of disease clustering and a generalized regression approach","volume":"27","author":"Mantel","year":"1967","journal-title":"Cancer Research"},{"key":"S0031182024001379_ref29","doi-asserted-by":"publisher","DOI":"10.1139\/z75-190"},{"key":"S0031182024001379_ref15","first-page":"101001","article-title":"First record of Dioctophyme renale (Goeze, 1782) in the pampas fox (Lycalopex gymnocercus, Fischer, 1814) (Carnivora: Canidae)","volume":"49","author":"Fern\u00e1ndez","year":"2024","journal-title":"Veterinary Parasitology: Regional Studies and Reports"},{"key":"S0031182024001379_ref11","doi-asserted-by":"publisher","DOI":"10.1590\/1678-5150-pvb-5744"},{"key":"S0031182024001379_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/147.2.915"},{"key":"S0031182024001379_ref38","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/97.1.145"},{"key":"S0031182024001379_ref57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602466103"},{"key":"S0031182024001379_ref34","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-736X2009001200001"},{"key":"S0031182024001379_ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8312.2008.01145.x"},{"key":"S0031182024001379_ref27","first-page":"772","article-title":"Partitionfinder 2: new methods for selecting partitioned models of evolution for molecular and morphological phylogenetic analyses","volume":"34","author":"Lanfear","year":"2017","journal-title":"Molecular Biology and Evolution"},{"key":"S0031182024001379_ref10","doi-asserted-by":"publisher","DOI":"10.31687\/saremNMS.2020.0.11"},{"key":"S0031182024001379_ref1","first-page":"165","article-title":"RStudio: integrated development environment for R","volume":"779","author":"Allaire","year":"2012","journal-title":"Boston MA"},{"key":"S0031182024001379_ref35","doi-asserted-by":"publisher","DOI":"10.1051\/limn:2007008"},{"key":"S0031182024001379_ref33","first-page":"357","volume-title":"Parasitic Diseases of Wild Mammals","author":"Measures","year":"2008"},{"key":"S0031182024001379_ref32","first-page":"171","article-title":"Macroscopic findings of lesions resulting from parasitism by Dioctophyma renale in Lobo-Guar\u00e1 (Chrysocyon brachyurus) \u2013 case report","volume":"XII","author":"Mattos Varzone","year":"2008","journal-title":"Ensaios e Ci\u00eancia: Ci\u00eancias Biol\u00f3gicas, Agr\u00e1rias e Da Sa\u00fade"},{"key":"S0031182024001379_ref48","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-017-2377-0"},{"key":"S0031182024001379_ref51","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msab120"},{"key":"S0031182024001379_ref50","first-page":"512","article-title":"Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees","volume":"10","author":"Tamura","year":"1993","journal-title":"Molecular Biology and Evolution"},{"key":"S0031182024001379_ref37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.10.5269"},{"key":"S0031182024001379_ref8","first-page":"420","article-title":"Prevalencia de un par\u00e1sito zoon\u00f3tico, Dioctophyma renale (Goeze, 1782), en caninos machos de una zona rivere\u00f1a al R\u00edo de la Plata, Provincia de Buenos Aires, Rep\u00fablica Argentina","volume":"43","author":"Burgos","year":"2015","journal-title":"Revista de Patologia Tropical"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182024001379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T11:30:42Z","timestamp":1762169442000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182024001379\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":58,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0031182024001379"],"URL":"https:\/\/doi.org\/10.1017\/s0031182024001379","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"\u00a9 The Author(s), 2024. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}