{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:12:58Z","timestamp":1769159578501,"version":"3.49.0"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Schistosomiasis is a parasitic disease that imposes a significant burden on society. The eggs are the primary pathogenic factor in schistosomiasis, and their accumulation in liver could lead to the formation of granulomas and liver fibrosis. However, the metabolic changes in liver resulting from schistosomiasis remain poorly understood. We established a mouse model of schistosomiasis japonica, where the eggs accumulate in the liver and form egg granulomas. We used mass spectrometry imaging to analyze the differences in metabolites among various liver regions, including the liver tissue from normal mice, the liver area outside the granulomas in schistosomiasis mice, and the granuloma region in schistosomiasis mice. There were significant differences in metabolites between different liver regions, which enriched in metabolic pathways such as the biosynthesis of unsaturated fatty acids, taurine and hypotaurine metabolism, glycerophospholipid metabolism, glycolysis\/gluconeogenesis, purine metabolism, arachidonic acid metabolism, and bile secretion. In normal liver tissue, higher concentrations of oleic acid (FA (18:1)), eicosapentaenoic acid (FA (20:5)), and L-glutamine were observed. In liver regions outside the granulomas, D-glucose and pyruvic acid were elevated compared to those in normal mice. Taurine increased in the liver of schistosomiasis. Meanwhile, there were elevated uric acid and spermidine in the egg granulomas. We employed mass spectrometry imaging technology to investigate metabolic reprogramming in liver of\n                    <jats:italic>Schistosoma japonicum<\/jats:italic>\n                    -infected mice. We explored the spatial distribution of differential metabolites in liver of schistosomiasis including unsaturated fatty acids, taurine, glutamine, spermidine, and uric acid. Our research provides valuable insights for further elucidating metabolic reprogramming in schistosomiasis.\n                  <\/jats:p>","DOI":"10.1017\/s0031182025000162","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T07:41:24Z","timestamp":1743147684000},"page":"1018-1026","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Spatial metabolomics to profile metabolic reprogramming of liver in\n                    <i>Schistosoma japonicum<\/i>\n                    -infected mice"],"prefix":"10.1017","volume":"152","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"Central South University"},{"name":"The Third Xiangya Hospital, Central South University"},{"name":"The Third Xiangya Hospital, Central South University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhui","family":"Li","sequence":"additional","affiliation":[{"name":"Central South University"},{"name":"The Third Xiangya Hospital, Central South University"},{"name":"The Third Xiangya Hospital, Central South University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Guo","sequence":"additional","affiliation":[{"name":"Central South University"},{"name":"The Third Xiangya Hospital, Central South University"},{"name":"The Third Xiangya Hospital, Central South University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Jiang","sequence":"additional","affiliation":[{"name":"Central South University"},{"name":"The Third Xiangya Hospital, Central South University"},{"name":"The Third Xiangya Hospital, Central South University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Central South University"},{"name":"The Third Xiangya Hospital, Central South University"},{"name":"The Third Xiangya Hospital, Central South University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gao","family":"Tan","sequence":"additional","affiliation":[{"name":"Hospital of the Hunan Provincial Corps of the People\u2019s Armed Police Force"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Liu","sequence":"additional","affiliation":[{"name":"Hospital of the Hunan Provincial Corps of the People\u2019s Armed Police Force"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2146-8394","authenticated-orcid":false,"given":"Yingzi","family":"Ming","sequence":"additional","affiliation":[{"name":"Central South University"},{"name":"The Third Xiangya Hospital, Central South University"},{"name":"The Third Xiangya Hospital, Central South University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"S0031182025000162_ref32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.609994"},{"key":"S0031182025000162_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.08.028"},{"key":"S0031182025000162_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2013.12.009"},{"key":"S0031182025000162_ref26","first-page":"3","article-title":"Autophagy is a critical regulator of memory CD8 (+) T cell formation","author":"Puleston","year":"2014","journal-title":"Elife"},{"key":"S0031182025000162_ref24","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4072"},{"key":"S0031182025000162_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2015.01.001"},{"key":"S0031182025000162_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.105120"},{"key":"S0031182025000162_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21785"},{"key":"S0031182025000162_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.08.005"},{"key":"S0031182025000162_ref14","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2018\/e150"},{"key":"S0031182025000162_ref34","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160809"},{"key":"S0031182025000162_ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0013-8"},{"key":"S0031182025000162_ref40","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2016.71"},{"key":"S0031182025000162_ref30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113285"},{"key":"S0031182025000162_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0354-4"},{"key":"S0031182025000162_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115074"},{"key":"S0031182025000162_ref23","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202048784"},{"key":"S0031182025000162_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv146"},{"key":"S0031182025000162_ref39","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-019-3621-6"},{"key":"S0031182025000162_ref44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008464"},{"key":"S0031182025000162_ref11","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00173-10"},{"key":"S0031182025000162_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2012.05.002"},{"key":"S0031182025000162_ref19","article-title":"Comparison of the Effects of Monounsaturated Fatty Acids and Polyunsaturated Fatty Acids on Liver Lipid Disorders in Obese Mice","volume":"15","author":"Liu","year":"2023","journal-title":"Nutrients"},{"key":"S0031182025000162_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.03.015"},{"key":"S0031182025000162_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.04.011"},{"key":"S0031182025000162_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2017.06.008"},{"key":"S0031182025000162_ref1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20220572"},{"key":"S0031182025000162_ref33","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physchem-061020-053416"},{"key":"S0031182025000162_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70053-1"},{"key":"S0031182025000162_ref37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404878101"},{"key":"S0031182025000162_ref21","doi-asserted-by":"publisher","DOI":"10.1126\/science.adi3025"},{"key":"S0031182025000162_ref9","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111564"},{"key":"S0031182025000162_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2012.05.035"},{"key":"S0031182025000162_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2016.01.003"},{"key":"S0031182025000162_ref35","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00615-8"},{"key":"S0031182025000162_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61949-2"},{"key":"S0031182025000162_ref43","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-5-27"},{"key":"S0031182025000162_ref7","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1212653"},{"key":"S0031182025000162_ref36","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18089163"},{"key":"S0031182025000162_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2023.08.002"},{"key":"S0031182025000162_ref15","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2015.122"},{"key":"S0031182025000162_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.03.008"},{"key":"S0031182025000162_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2014.01.002"},{"key":"S0031182025000162_ref20","doi-asserted-by":"publisher","DOI":"10.1021\/ac400009s"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182025000162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T07:21:04Z","timestamp":1763364064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182025000162\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0031182025000162"],"URL":"https:\/\/doi.org\/10.1017\/s0031182025000162","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,28]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}